| 中文名称 | Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate |
|---|---|
| 中文同义词 | |
| 英文名称 | Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate |
| 英文同义词 | Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate |
| CAS号 | 1402931-66-1 |
| 分子式 | C28H29NO7 |
| 分子量 | 491.53 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1402931-66-1.mol |
| 结构式 | ![Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate 结构式](CAS/20210305/GIF/1402931-66-1.gif) |
Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate 性质
| 沸点 | 640.7±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.362±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) |
| 酸度系数(pKa) | 11.79±0.70(Predicted) |
Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate 用途与合成方法
eIF4A3-IN-15 (compound 52) 是 silvestrol (HY-13251) 类似物。eIF4A3-IN-15 干扰 eIF4F 翻译复合体组装，对 myc-LUC，tub-LUC 和抑制 MBA-MB-231 细胞生长的 EC50 值分别为 11，700 和 120 nM。eIF4A3-IN-15 可用于人类肿瘤发病机制的研究。