Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate

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Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate Basic information
Product Name:Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate
Synonyms:Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate
CAS:1402931-66-1
MF:C28H29NO7
MW:491.53
EINECS:
Product Categories:
Mol File:1402931-66-1.mol
Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate Structure
Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate Chemical Properties
Boiling point 640.7±55.0 °C(Predicted)
density 1.362±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka11.79±0.70(Predicted)
Safety Information
MSDS Information
Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate Usage And Synthesis
UseseIF4A3-IN-15 (compound 52) is a silvestrol (HY-13251) analogue. eIF4A3-IN-15 interferes the assembling of eIF4F translation complex with EC50s of 11, 700 and 120 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-15 can be used for the research of human cancer pathogenesis[1].
References[1] Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. DOI:10.1021/jm3011542
Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate Preparation Products And Raw materials
Tag:Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate(1402931-66-1) Related Product Information
(S)-(-)-2-Azetidinecarboxylic acid ISRIB eIF4A3-IN-2 (1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-Dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester A-92 2BAct(eIF2B activator 2BAct)