137338-43-3
| 中文名称 | 137338-43-3 |
|---|---|
| 中文同义词 | 化合物 T15714;化合物 LAS-31180 |
| 英文名称 | LAS 31180 |
| 英文同义词 | LAS 31180;Methanesulfonamide, N-(1,4-dihydro-1-methyl-4-oxo-3-quinolinyl)-;LAS 31180,LAS31180;3-Methylsulfonylamino-1-methyl-4(1H)-quinolone |
| CAS号 | 137338-43-3 |
| 分子式 | C11H12N2O3S |
| 分子量 | 252.29 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 137338-43-3.mol |
| 结构式 |  |
137338-43-3 性质
| 沸点 | 386.7±52.0 °C(Predicted) |
|---|---|
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 5.70±0.20(Predicted) |
LAS-31180 是一种 phosphodiesterase 3 的抑制剂，能够增强肌肉收缩和血管舒张。
LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC 50 of 1.2 mumol/L) and in isolated guinea-pig working hearts.
In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure.