ONO-LB 457

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:ONO4057；ONO-LB457
CAS:134578-96-4
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
Tel: 13564774135
Email: marketing@targetmol.com
Products Intro: Product Name:ONO4057
CAS:134578-96-4
Purity:100% Package:1mg;700USD|5mg;1800USD
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Products Intro: Product Name:ONO-4057
CAS:134578-96-4
Purity:98% Remarks:Reach out to us for more information about custom solutions.
Company Name: MedChemexpress LLC  
Tel: 021-58955995
Email: sales@medchemexpress.cn
Products Intro: Product Name:ONO4057
CAS:134578-96-4
Purity:1600RMB/1mg Package:>98%
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Products Intro: Product Name:ONO-LB 457
CAS:134578-96-4
Purity:98% Package:1g;10g;100g

ONO-LB 457 manufacturers

  • ONO4057
  • ONO4057 pictures
  • $700.00
  • 2026-07-14
  • CAS:134578-96-4
  • Purity: 100.00%
  • Supply Ability: 10g
ONO-LB 457 Basic information
Product Name:ONO-LB 457
Synonyms:ONO-LB 457;ONO-4057;Benzenepropanoic acid, 2-(4-carboxybutoxy)-6-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-;ONO-4057,ONO4057
CAS:134578-96-4
MF:C27H34O7
MW:470.55
EINECS:
Product Categories:
Mol File:134578-96-4.mol
ONO-LB 457 Structure
ONO-LB 457 Chemical Properties
Boiling point 704.8±60.0 °C(Predicted)
density 1.173±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka4.68±0.10(Predicted)
Safety Information
MSDS Information
ONO-LB 457 Usage And Synthesis
UsesONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM.
in vivo

Mean animal survivals of the ONO4057-treated animals significantly prolong to 21.0±4.4 days compare with 12.0±0.6 days in control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated anmimals is milder than that in control group[2].

IC 50LTB4: 0.7 μM (IC50)
References[1] Kishikawa K, et al. ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75. DOI:10.1016/0090-6980(92)90002-b
[2] Tanaka M, et al. Effect of leukotriene B(4) receptor antagonist (ONO4057) on hepatic allografting in rats. Transplant Proc. 2000 Nov;32(7):2340. DOI:10.1016/s0041-1345(00)01690-0
ONO-LB 457 Preparation Products And Raw materials
Tag:ONO-LB 457(134578-96-4) Related Product Information
3-(2-METHOXYPHENYL)PROPIONIC ACID ONO-LB 457 4-(4-Ethoxy-3,5-dimethyl-phenyl)-butyric acid 3-(4-Ethoxy-2-methoxy-phenyl)-propionic acid 5-Benzofuranbutanoic acid, 2,3-dihydro- LY 223982