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| | heptelidic acid Basic information |
| Product Name: | heptelidic acid | | Synonyms: | heptelidic acid;(5aS,9S)-1,5a,6,7,8,9aα-Hexahydro-6β-(1-methylethyl)-1-oxospiro[2-benzoxepine-9(3H),2'-oxirane]-4-carboxylic acid;(5aS,9S)-1,5aβ,6,7,8,9aα-Hexahydro-6β-isopropyl-1-oxospiro[2-benzoxepine-9(3H),2'-oxirane]-4-carboxylic acid;Avocettin;Koningic acid;Spiro[2-benzoxepin-9(3H),2'-oxirane]-4-carboxylic acid, 1,5a,6,7,8,9a-hexahydro-6-(1-methylethyl)-1-oxo-, (2'S,5aS,6R,9aS)- | | CAS: | 57710-57-3 | | MF: | C15H20O5 | | MW: | 280.32 | | EINECS: | | | Product Categories: | | | Mol File: | 57710-57-3.mol |  |
| | heptelidic acid Chemical Properties |
| Boiling point | 501.1±50.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | | form | A solid | | pka | 3.68±0.40(Predicted) | | color | Colorless to off-white | | LogP | 2.034 (est) |
| | heptelidic acid Usage And Synthesis |
| Uses | Heptalidic acid is asesquiterpene lactone and found to inhibit etoposide-induced apoptosis in human leukemia U937 cells. In addition, it alsoinhibit mammalian DNA polymerases and terminal deoxynucleotidyl transferase. | | in vivo | Heptelidic acid (Koningic acid; KA) is bioavailable and induces dynamic changes to glycolysis in vivo[3]. | Animal Model: | 6-week old female Foxn1nu mice bearing BT-474 tumor[3] | | Dosage: | 1, 2.5, 5, and 10 mg/kg | | Administration: | Daily intraperitoneal (IP) injections, 24 hours | | Result: | 1 mg/kg was determined to be the maximum tolerated dose (MTD) based upon behavioral monitoring and adverse events at higher doses (hemolysis, hematuria, and anemia).
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| | IC 50 | Caspase-3 |
| | heptelidic acid Preparation Products And Raw materials |
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