pinane-thromboxane A2 manufacturers
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| | pinane-thromboxane A2 Basic information |
| Product Name: | pinane-thromboxane A2 | | Synonyms: | (1S-(1alpha,2beta(Z),3alpha(1E,3S*),5alpha))-7-(3-(3-Hydroxy-1-octenyl)-6,6-dimethylbicyclo(3.1.1)hept-2-yl)-5-heptenoic acid;OHJIHGVLRDHSDV-PUYXBYOHSA-N;5-Heptenoic acid, 7-[(1S,2R,3R,5S)-3-[(1E,3R)-3-hydroxy-1-octen-1-yl]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-, (5Z)- | | CAS: | 71154-83-1 | | MF: | C24H40O3 | | MW: | 376.57 | | EINECS: | | | Product Categories: | | | Mol File: | 71154-83-1.mol |  |
| | pinane-thromboxane A2 Chemical Properties |
| Boiling point | 508.612±25.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.023±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): .15 mg/ml | | pka | 4.761±0.10(predicted) |
| | pinane-thromboxane A2 Usage And Synthesis |
| Description | 15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 (PTA2; ). 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM).1 It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.2 | | Uses | 15(R)-PTA2 (15(R)-Pinanethromboxane A2) is an antithrombotic agent that inhibits platelet aggregation. 15(R)-PTA2 inhibits stable prostaglandin endoperoxide analog-induced constriction of feline coronary arteries and stabilizes hepatic lysosomes. 15(R)-PTA2 also inhibits thromboxane synthase but has no effect on prostacyclin synthase[1]. | | References | 1. Caton, M.P.L., Stuttle, K.A.J., Tuffin, D.P., et al. Comparative action of carbocyclic thromboxane A2 stereoisomers on platelets Eur. J. Med. Chem. 35(12),1099-1107(2000).
2. Bennett, A., and Sanger, G.J. Pinane thromboxane A2 analogues are non-selective prostanoid antagonists in rat and human stomach muscle Br. J. Pharmacol. 77(4),591-596(1982). |
| | pinane-thromboxane A2 Preparation Products And Raw materials |
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