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| | 3-Morpholin-4-ylmethylbenzoic acid Basic information |
| Product Name: | 3-Morpholin-4-ylmethylbenzoic acid | | Synonyms: | AKOS BB-9413;3-Morpholin-4-ylmethylbenzoicacid95%;3-MORPHOLIN-4-YLMETHYLBENZOIC ACID 95%;3-(4-Morpholinylmethyl)Benzoic acid;3-(Morpholinomethyl);3-(Morpholinomethyl)benzoic Acid;Benzoic acid, 3-(4-morpholinylmethyl)-;3-Morpholin-4-ylmethylbenzoic acid | | CAS: | 67451-81-4 | | MF: | C12H15NO3 | | MW: | 221.25 | | EINECS: | | | Product Categories: | | | Mol File: | 67451-81-4.mol |  |
| | 3-Morpholin-4-ylmethylbenzoic acid Chemical Properties |
| Boiling point | 376.9±32.0 °C(Predicted) | | density | 1.233±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 3.98±0.10(Predicted) | | Appearance | White to off-white Solid |
| Hazard Codes | Xn | | Risk Statements | 22 |
| | 3-Morpholin-4-ylmethylbenzoic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-morpholin-4-ylmethylbenzoic acid from methyl 3-(4-morpholinylmethyl)benzoate: to a solution of methyl 3-(4-morpholinylmethyl)benzoate (5.02 g, 21.0 mmol) in methanol (100 mL) was added a sodium hydroxide solution (21.0 mL, 42.0 mmol, 2M). The reaction mixture was heated at 50 °C with stirring for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was adjusted to pH=3 with 1M hydrochloric acid and the resulting suspension was subsequently filtered. The collected solid was dissolved in acetonitrile (15 mL) and concentrated to afford 3-(morpholin-4-ylmethyl)benzoic acid (4.6 g, 100% yield) as a white solid, which was used directly in the subsequent reaction without further purification. | | References | [1] Patent: WO2018/169777, 2018, A1. Location in patent: Paragraph 0229 |
| | 3-Morpholin-4-ylmethylbenzoic acid Preparation Products And Raw materials |
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