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| | QUININE Basic information |
| Product Name: | QUININE | | Synonyms: | (22R,25R)-5α-Spirosolane-3β-ol;Soladulcidine;(2aS,2'R,4S,5'R,6aS,6bS,8aS,8bR,9S,11aS,12aS,12bR)-5',6a,8a,9-tetramethyloctadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-piperidin]-4-ol;Spirosolan-3-ol, (3β,5α,22α,25R)-;Spirosolan-3-ol, (3b,5a,22a,25R)-;Dihydrosolasodine | | CAS: | 511-98-8 | | MF: | C27H45NO2 | | MW: | 415.65 | | EINECS: | | | Product Categories: | Alkaloids;1 | | Mol File: | 511-98-8.mol |  |
| | QUININE Chemical Properties |
| Melting point | 209- 211°C | | Boiling point | 527.2±25.0 °C(Predicted) | | density | 1.10±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | Methanol (Slightly, Heated) | | form | Solid | | pka | 15.14±0.70(Predicted) | | color | Pale Brown |
| | QUININE Usage And Synthesis |
| Description | This alkaloid from Solanum dulcamara forms colourless plates when crystallized from MeOH. It is laevorotatory with [α]D - 50° (c 0.4, CHCI3). The alkaloid forms the O,N-diformyl derivative which exists as two rotational isomers, the trans with m.p. 222-4°C; [α]20D - 21.2° (CHCI3) and the cis isomer with m.p. 202-4°C; [α]20D - 69.6° (CHCI3). | | Uses | Soladulcidine is a steroidal glycoalkaloid extracted from tomato leaves and berries and can induce craniofacial malformations in hamsters. | | Definition | ChEBI: Soladulcidine is an azaspiro compound, a steroid and an oxaspiro compound. | | References | Schreiber., Planta Med., 6,93 (1958)
Alkemeyer, Sandor., Naturwiss., 46, 207 (1959)
Schreiber, Adam., Experientia, 17,13 (1961)
Schreiber, Adam., Annalen, 666, 155 (1963)
Synthesis:
Adam, Schreiber., Experientia, 21,471 (1965)
Adam, Schreiber., Tetrahedron, 22, 3591 (1966)
Absolute configuration:
Boll, von Philipsborn., Acta Chem. Scand., 19,1365 (1965) |
| | QUININE Preparation Products And Raw materials |
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