ONCOII

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ONCOII Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
ONCOII Basic information
Product Name:ONCOII
Synonyms:ONCOII;3-Pyridinecarbonitrile, 6-[[3-(cyanomethoxy)-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino]-2-(cyclohexylamino)-
CAS:1263564-94-8
MF:C24H25N7O
MW:427.5
EINECS:
Product Categories:
Mol File:1263564-94-8.mol
ONCOII Structure
ONCOII Chemical Properties
Boiling point 648.925±55.00 °C(Press: 760.00 Torr)(predicted)
density 1.282±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka1.995±0.10(predicted)
Safety Information
MSDS Information
ONCOII Usage And Synthesis
UsesONCOII is an Mps1 inhibitor with an IC50 of 10.8 nM. The inhibitory activity of ONCOII against Mps1 is affected by naturally occurring mutations in the Mps1 gene, and cells with Mps1 mutations exhibit increased resistance to ONCOII. ONCOII can be used in cancer research[1].
References[1] Gurden MD, et al. Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res. 2015 Aug 15;75(16):3340-54. DOI:10.1158/0008-5472.CAN-14-3272
ONCOII Preparation Products And Raw materials
Tag:ONCOII(1263564-94-8) Related Product Information
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide BAY-1217389 NTRC 00660 MPS1-IN-3 Mps1-IN-5 CFI-400936