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| Product Name: | FL442 | | Synonyms: | FL442;Benzonitrile, 4-(3a,4,5,6,7,7a-hexahydro-1,2-benzisoxazol-3-yl)-2-(trifluoromethyl)- | | CAS: | 1431166-12-9 | | MF: | C15H13F3N2O | | MW: | 294.27 | | EINECS: | | | Product Categories: | | | Mol File: | 1431166-12-9.mol |  |
| | FL442 Chemical Properties |
| Boiling point | 387.206±52.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.397±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| | FL442 Usage And Synthesis |
| Uses | FL442 is an Androgen Receptor (AR) modulator. FL442 exhibits strong inhibitory effects in AR-dependent prostate cancer cells, showing similar inhibitory efficiency to traditional antiandrogen drugs Bicalutamide (HY-14249) and Enzalutamide (HY-70002), while maintaining antiandrogenic activity against the AR mutant F876L, which is highly resistant to Enzalutamide. Pharmacokinetic studies of FL442 in mice reveal a long half-life (8 hours), good targeting (prostate tissue), and metabolic stability, and it effectively inhibits LNCaP tumor growth at low plasma concentrations (30 ng/mL)[1]. | | References | [1] Poutiainen PK, et al. Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator. Mol Cell Endocrinol. 2014 Apr 25;387(1-2):8-18. DOI:10.1016/j.mce.2014.02.008 |
| | FL442 Preparation Products And Raw materials |
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