| Company Name: |
LGM Pharma |
| Tel: |
1-(800)-881-8210 |
| Email: |
inquiries@lgmpharma.com |
| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
3-Nitro-5-phenylacetyl catechol manufacturers
- Nebicapone
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- $1520.00
-
2026-07-15
- CAS:274925-86-9
- Purity:
- Supply Ability: 10g
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| | 3-Nitro-5-phenylacetyl catechol Basic information |
| | 3-Nitro-5-phenylacetyl catechol Chemical Properties |
| Melting point | 178–179°C | | Boiling point | 454.2±45.0 °C(Predicted) | | density | 1.435±0.06 g/cm3(Predicted) | | pka | 5.01±0.38(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | 3-Nitro-5-phenylacetyl catechol Usage And Synthesis |
| Uses | Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease[1]. | | Preparation | Preparation by treatment of 1-(4-hydroxy-3- methoxy-5-nitrophenyl)-2-phenylethanone with aluminium chloride in refluxing ethyl acetate/ pyridine mixture for 2 h (99%). | | References | [1] Loureiro AI, et al. Human metabolism of nebicapone (BIA 3-202), a novel catechol-o-methyltransferase inhibitor: characterization of in vitro glucuronidation. Drug Metab Dispos. 2006 Nov;34(11):1856-62. DOI:10.1124/dmd.106.010447 |
| | 3-Nitro-5-phenylacetyl catechol Preparation Products And Raw materials |
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