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| | ISOVALERYL-L-CARNITINE CHLORIDE Basic information |
| Product Name: | ISOVALERYL-L-CARNITINE CHLORIDE | | Synonyms: | ISOVALERYL-L-CARNITINE CHLORIDE;L-CARNITINE:HCL, O-ISOVALERYL UNLABELED;Isovaleryl-L-carnitine-d3 HCl (N-methyl-d3);1-Propanaminium,3-carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-, chloride, (2R)-;Isovalerylcarnitine chloride;Isovaleryl-L-carnitine HCl in Water | | CAS: | 139144-12-0 | | MF: | C12H22ClNO3 | | MW: | 263.76098 | | EINECS: | | | Product Categories: | | | Mol File: | 139144-12-0.mol |  |
| | ISOVALERYL-L-CARNITINE CHLORIDE Chemical Properties |
| Melting point | >160°C (dec.) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Methanol (Slightly), Water (Slightly, Heated) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic | | CAS Number Unlabeled | 139144-12-0 |
| | ISOVALERYL-L-CARNITINE CHLORIDE Usage And Synthesis |
| Description | Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia). | | Uses | Isovaleryl L-Carnitine Chloride is used to prepare carnitine benzyl esters as neuroprotectant prodrugs. | | IC 50 | Human Endogenous Metabolite | | References | [1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] ROBERTO PAOLO REVOLTELLA . l-Carnitine and some of its analogs delay the onset of apoptotic cell death initiated in murine C2.8 hepatocytic cells after hepatocyte growth factor deprivation[J]. Biochimica et biophysica acta. Molecular cell research, 1994, 1224 3: Pages 333-341. DOI: 10.1016/0167-4889(94)90265-8
[3] G MIOTTO. Control of hepatic proteolysis by leucine and isovaleryl-L-carnitine through a common locus. Evidence for a possible mechanism of recognition at the plasma membrane.[J]. The Journal of Biological Chemistry, 1992, 267 31: 22066-22072.
[4] PIERO RINALDO Dietrich M Tina M Cowan. Acylcarnitine profile analysis[J]. Genetics in Medicine, 2008, 10 2: Pages 151-156. DOI: 10.1097/gim.0b013e3181614289 |
| | ISOVALERYL-L-CARNITINE CHLORIDE Preparation Products And Raw materials |
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