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2-Chloro-4-methylquinazoline

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2-Chloro-4-methylquinazoline Basic information
Product Name:2-Chloro-4-methylquinazoline
Synonyms:2-Chloro-4-methylquinazoline;Quinazoline, 2-chloro-4-methyl-
CAS:6141-14-6
MF:C9H7ClN2
MW:178.62
EINECS:
Product Categories:API intermediates
Mol File:6141-14-6.mol
2-Chloro-4-methylquinazoline Structure
2-Chloro-4-methylquinazoline Chemical Properties
Boiling point 262.8±23.0 °C(Predicted)
density 1.292±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka0.94±0.30(Predicted)
AppearanceWhite to yellow Solid
Safety Information
MSDS Information
2-Chloro-4-methylquinazoline Usage And Synthesis
Synthesis
4-methylquinazolin-2(1H)-one

34790-24-4

2-Chloro-4-methylquinazoline

6141-14-6

2-Chloro-4-methylquinazoline was prepared by reacting 4-methylquinazolin-2(3H)-one as starting material in the presence of phosphorus trichloride and hydrochloric acid, referring to the method of Example 27c. The reaction yield was 67% of the theoretical value, and the product was detected by thin layer chromatography (silica gel plate, unfolding agent was petroleum ether/ethyl acetate=7:3) with an Rf value of 0.81.

References[1] Patent: US6200976, 2001, B1
[2] Chemical Communications, 2014, vol. 50, # 33, p. 4302 - 4304
[3] Patent: WO2005/123714, 2005, A1. Location in patent: Page/Page column 7
2-Chloro-4-methylquinazoline Preparation Products And Raw materials
Raw materials4-methylquinazolin-2(1H)-one-->Hydrochloric acid-->trichlorophosphate
Tag:2-Chloro-4-methylquinazoline(6141-14-6) Related Product Information
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