6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline

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6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline Basic information
Product Name:6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline
Synonyms:6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline;Isoquinoline-6-boronic acid pinacol ester;6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOQUINOLINE 97%;Isoquinoline-6-boronic acid picol ester;Isoquinoline, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline (>85%)
CAS:675576-26-8
MF:C15H18BNO2
MW:255.12
EINECS:
Product Categories:
Mol File:675576-26-8.mol
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline Structure
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline Chemical Properties
Melting point 179-184°C
Boiling point 397.5±15.0 °C(Predicted)
density 1.10±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form solid
pka5.03±0.14(Predicted)
AppearanceOff-white to light yellow Solid
InChI1S/C15H18BNO2/c1-14(2)15(3,4)19-16(18-14)13-6-5-12-10-17-8-7-11(12)9-13/h5-10H,1-4H3
InChIKeyLFALMDZWCMSBFO-UHFFFAOYSA-N
SMILESCC1(C)OB(OC1(C)C)c2ccc3cnccc3c2
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline Usage And Synthesis
UsesUseful boron compound for Suzuki coupling.
SynthesisA mixture of 6-bromoisoquinoline (208 mg, 1 mmol), bis(pinacolato)diboronate (279 mg, 1.1 mmol), KOAc (323 mg, 3.3 mmol) and Pd(dppf)2Cl2 (73 mg, 0.1 mmol) in DMSO (3 mL) was heated in microwave at 160 C for 10 minutes. The mixture was diluted with water (20 mL) and extracted with EtOAc (4x 20 mL). The combined EtOAc was washed with water (15 mL) and brine (15 mL) and dried (Na2SO4). The solvent was removed to give isoquinoline-6-boronic acid pinacol ester.
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline Preparation Products And Raw materials
Tag:6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline(675576-26-8) Related Product Information
Isoquinoline-3-carboxylic acid C-Isoquinolin-4-yl-methylamine Methyl 4-isoquinolinecarboxylate Isoquinoline-5-carboxylic acid Isothiazolo[5,4-b]pyridin-6-amine 8-isoquinolinyl-boronic acid Isoquinoline-3-carboxylic acid ISOQUINOLIN-3-AMINE Isoquinoline-1-carboxylic acid ethyl ester Isoquinoline-4-carbaldehyde 6-Isoquinolinecarboxaldehyde (9CI)