Sp-Thymidine-5'-O-(1-thiotriphosphate) (sodium salt)

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Sp-Thymidine-5'-O-(1-thiotriphosphate) (sodium salt) Suppliers list
Company Name: Cayman Chemical Company  
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Email: sales@caymanchem.com
Sp-Thymidine-5'-O-(1-thiotriphosphate) (sodium salt) Basic information
Product Name:Sp-Thymidine-5'-O-(1-thiotriphosphate) (sodium salt)
Synonyms:Sp-Thymidine-5'-O-(1-thiotriphosphate) (sodium salt);Sp-Thymidine-5'-O-(1-thiotriphosphate) (sodium salt)
CAS:
MF:
MW:0
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Mol File:Mol File
Sp-Thymidine-5'-O-(1-thiotriphosphate) (sodium salt) Structure
Sp-Thymidine-5'-O-(1-thiotriphosphate) (sodium salt) Chemical Properties
solubility Water: Soluble
Safety Information
MSDS Information
Sp-Thymidine-5'-O-(1-thiotriphosphate) (sodium salt) Usage And Synthesis
DescriptionSp-Thymidine-5'-O-(1-thiotriphosphate) (Sp-TTP-α-S) is an isomer of the sulfur-containing nucleotide derivative TTP-α-S.1 It binds to HIV-1 reverse transcriptase (Kds = 2.88, 4.23, and 20.21 µM in the presence of magnesium, manganate, and cobalt, respectively). Sp-TTP-α-S inhibits deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Ki = 46 nM).2WARNING This product is not for human or veterinary use.
References[1] JESSICA RADZIO  Nicolas S C. Stereo-selectivity of HIV-1 reverse transcriptase toward isomers of thymidine-5’-O-1-thiotriphosphate.[J]. Protein Science, 2005: 1929-1933. DOI: 10.1110/ps.051445605
[2] ELIZABETH R. MORRIS. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers[J]. Biochemistry Biochemistry, 2021, 60 21: 1682-1698. DOI: 10.1021/acs.biochem.0c00944
Sp-Thymidine-5'-O-(1-thiotriphosphate) (sodium salt) Preparation Products And Raw materials
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