Sp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt)

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Sp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt) Basic information
Product Name:Sp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt)
Synonyms:Sp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt);Sp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt)
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MW:0
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Mol File:Mol File
Sp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt) Structure
Sp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt) Chemical Properties
solubility Water: Soluble
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MSDS Information
Sp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt) Usage And Synthesis
DescriptionSp-Adenosine-5'-O-(1-thiotriphosphate) (Sp-ATP-α-S) is an isomer of the sulfur-containing nucleotide derivative ATP-α-S and an agonist of the purinergic P2Y1 receptor.1 It increases calcium mobilization in HEK293 cells expressing the P2Y1 receptor (EC50 = 9.4 nM for the human receptor). Sp-ATP-α-S inhibits ADP-induced aggregation of isolated human platelets (Ki = 4 μM).2 It induces relaxation of carbamoylcholine-preconstricted guinea pig taenia coli (EC50 = 426 nM).3WARNING This product is not for human or veterinary use.
References[1] DAN T. MAJOR. Molecular Recognition in Purinergic Receptors. 2. Diastereoselectivity of the h-P2Y1-Receptor†[J]. Journal of Medicinal Chemistry, 2004, 47 18: 4405-4416. DOI: 10.1021/jm049771u
[2] ASHOK AGARWAL. Evaluation of the Binding to Fixed Platelets of Agonists and Antagonists of ADP-Induced Aggregation[J]. Thrombosis and haemostasis, 1989, 67 1: 1103-1106. DOI: 10.1055/s-0038-1647126
[3] G. BURNSTOCK  L. A M  N J Cusack. Effects of phosphorothioate analogues of ATP, ADP and AMP on guinea-pig taenia coli and urinary bladder[J]. British Journal of Pharmacology, 1984, 82 2: 369-374. DOI: 10.1111/j.1476-5381.1984.tb10771.x
Sp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt) Preparation Products And Raw materials
Tag:Sp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt) Related Product Information
Adenosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid, tetrasodium salt (9CI) Sp-Thymidine-5'-O-(1-thiotriphosphate) (sodium salt) Sp-Uridine-5'-O-(1-thiotriphosphate) (sodium salt) Adenosine, 5′→P′-ester with [P′(S)]-thiodiphosphoric acid ((HO)2P(O)OP(O)(OH)(SH)), sodium salt (1:3) Rp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt)