2'-O-Methylguanosine-5'-O-triphosphate (sodium salt)

Request For Quotation
2'-O-Methylguanosine-5'-O-triphosphate (sodium salt) Suppliers list
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Email: sales@caymanchem.com
Products Intro: Product Name:2'-O-Methylguanosine-5'-O-triphosphate (sodium salt)
2'-O-Methylguanosine-5'-O-triphosphate (sodium salt) Basic information
Product Name:2'-O-Methylguanosine-5'-O-triphosphate (sodium salt)
Synonyms:2'-O-Methylguanosine-5'-O-triphosphate (sodium salt);2'-O-Methylguanosine-5'-O-triphosphate (sodium salt)
CAS:
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
2'-O-Methylguanosine-5'-O-triphosphate (sodium salt) Structure
2'-O-Methylguanosine-5'-O-triphosphate (sodium salt) Chemical Properties
solubility Water: Soluble
Safety Information
MSDS Information
2'-O-Methylguanosine-5'-O-triphosphate (sodium salt) Usage And Synthesis
Description2'-O-Methylguanosine-5'-O-triphosphate (2’-methyl GTP) is an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50 = 3.5 µM) and an active metabolite of the prodrug IDX184.1,2 It is formed from IDX184 via a 2’-methylguanosine (Item No. 21039) intermediate.2 2’-methyl GTP (50 µM) also induces tubulin polymerization.3 Tumoral levels of 2’-methyl GTP are decreased in patients with hepatocellular carcinoma compared with adjacent normal tissue.4WARNING This product is not for human or veterinary use.
References[1] HÉLÈNE DUTARTRE. A relaxed discrimination of 2’-O-methyl-GTP relative to GTP between de novo and Elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B.[J]. The Journal of Biological Chemistry, 2005, 280 8: 6359-6368. DOI: 10.1074/jbc.m410191200
[2] XIAO-JIAN ZHOU. Safety and pharmacokinetics of IDX184, a liver-targeted nucleotide polymerase inhibitor of hepatitis C virus, in healthy subjects.[J]. Antimicrobial Agents and Chemotherapy, 2011, 55 1: 76-81. DOI: 10.1128/aac.01101-10
[3] ERNEST HAMEL. Modulation of tubulin-nucleotide interactions by microtubule-associated proteins: polymerization with ribose-modified analogs of guanosine 5’-triphosphate[J]. Biochemistry Biochemistry, 1983, 22 5: 1271-1279. DOI: 10.1021/bi00274a044
[4] JIANG H P, XIONG J, LIU F L, et al. Modified nucleoside triphosphates exist in mammals†[J]. Chemical Science, 2018, 17: 4160-4167. DOI: 10.1039/c7sc05472f
2'-O-Methylguanosine-5'-O-triphosphate (sodium salt) Preparation Products And Raw materials
Tag:2'-O-Methylguanosine-5'-O-triphosphate (sodium salt) Related Product Information
Guanosine 5'-(tetrahydrogen triphosphate), 3'-O-methyl-, tetrasodium salt (9CI) 2-Aminoadenosine-5'-O-triphosphate (sodium salt) 7-Deazaadenosine-5'-O-triphosphate (sodium salt) Adenosine 5′-(tetrahydrogen triphosphate), 2′,3′-dideoxy-, tetrasodium salt 2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt)