2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt)

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2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt) Suppliers list
Company Name: Shanghai meikai technology co., ltd  
Tel: 021-68689288 15300790979
Email: info@mkbio.com.cn
Products Intro: Product Name:2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt)
Purity:95%
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Email: sales@caymanchem.com
Products Intro: Product Name:2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt)
2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt) Basic information
Product Name:2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt)
Synonyms:2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt);2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt)
CAS:
MF:
MW:0
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Mol File:Mol File
2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt) Structure
2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt) Chemical Properties
solubility Water: Soluble
Safety Information
MSDS Information
2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt) Usage And Synthesis
Description2',3'-Dideoxythymidine-5'-O-triphosphate (ddTTP) is a reverse transcriptase inhibitor (Kis = 40 and 25 nM for the visna virus and HIV-1 enzymes, respectively).1,2 It also inhibits DNA polymerase γ (Ki = 400 nM for the bovine enzyme).3 ddTTP has been used to terminate chain extension produced by the Taq polymerase in PCR assays.4WARNING This product is not for human or veterinary use.
References[1] K B FRANK. Visna virus as an in vitro model for human immunodeficiency virus and inhibition by ribavirin, phosphonoformate, and 2’,3’-dideoxynucleosides.[J]. Antimicrobial Agents and Chemotherapy, 1987, 31 9: 1369-1374. DOI: 10.1128/aac.31.9.1369
[2] T UENO  H M  T Shirasaka. Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2’,3’-dideoxynucleoside 5’-triphosphates.[J]. The Journal of Biological Chemistry, 1995, 270 40: 23605-23611. DOI: 10.1074/jbc.270.40.23605
[3] SHUNJI IZUTA . The 5′-triphosphates of 3′-azido-3′-deoxythymidine and 2′, 3′-dideoxynucleosides inhibit DNA polymerase γ by different mechanisms[J]. Biochemical and biophysical research communications, 1991, 179 2: Pages 776-783. DOI: 10.1016/0006-291x(91)91884-f
[4] Y LI  G W  V Mitaxov. Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1999, 96 17: 9491-9496. DOI: 10.1073/pnas.96.17.9491
2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt) Preparation Products And Raw materials
Tag:2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt) Related Product Information
DDGTP SODIUM SALT 2'-O-Methylguanosine-5'-O-triphosphate (sodium salt) 7-Deazaadenosine-5'-O-triphosphate (sodium salt) 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE SODIUM SALT Adenosine 5′-(tetrahydrogen triphosphate), 2′,3′-dideoxy-, tetrasodium salt