1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane HCl

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1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane HCl manufacturers

  • CL-216303 HCl
  • CL-216303 HCl pictures
  • $1980.00
  • 2026-05-11
  • CAS:86215-36-3
  • Purity:
  • Supply Ability: 10g
1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane HCl Basic information
Product Name:1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane HCl
Synonyms:1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hydrochloride;1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hychloride;DOV216303 HCl;CL 216303;CL216303;CL-216303;CL-216303 HCl;CL216303 HCl,CL 216303 HCl
CAS:86215-36-3
MF:C11H12Cl3N
MW:264.58
EINECS:
Product Categories:pharmacetical
Mol File:86215-36-3.mol
1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane HCl Structure
1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane HCl Chemical Properties
storage temp. -20°C
solubility DMSO: ≥10mg/mL
form powder
color white to beige
InChI1S/C11H11Cl2N.ClH/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11;/h1-3,8,14H,4-6H2;1H
InChIKeyKAGBHVBIOJBGBD-UHFFFAOYSA-N
SMILESCl.Clc1ccc(cc1Cl)C23CNCC2C3
CAS DataBase Reference86215-36-3
Safety Information
Hazard Codes T
Risk Statements 25-36
Safety Statements 26-45
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
Storage Class6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard ClassificationsAcute Tox. 3 Oral
Eye Irrit. 2
MSDS Information
1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane HCl Usage And Synthesis
UsesDOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3].
Biological ActivityTriple reuptake inhibitor (TRI); serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI); IC50 values of ~20, 14, and 78 nM, respectively.
References[1] Skolnick P, et al. Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. CNS Drug Rev. 2006 Summer;12(2):123-34. DOI:10.1111/j.1527-3458.2006.00123.x
[2] Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. DOI:10.1016/j.bmcl.2011.01.016
[3] Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61. DOI:10.1095/biolreprod44.3.561
1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane HCl Preparation Products And Raw materials
Tag:1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane HCl(86215-36-3) Related Product Information
3-(4-chlorophenyl)piperidine cyclopropyl(phenyl)methanamine C-[1-(3-Chloro-phenyl)-cyclopropyl]-methylamine C-[1-(4-Chloro-phenyl)-cyclopropyl]-methylamine 1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane HCl 3-Azabicyclo[3.1.0]hexane, 1-(4-bromophenyl)-, hydrochloride (1:1), (1R,5S)-