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STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1 manufacturers
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| | STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1 Basic information |
| Product Name: | STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1 | | Synonyms: | PAMAM dendrimer, ethylenediamine core, generation 1.0 solution 20 wt. % in methanol;STARBURST (PAMAM) DENDRIMER, GENERATION 1, 20 WT. % SOLUTION IN METHYL ALCOHOL;pamam dendrimer, generation 1 solution;PAMAM dendrimer, ethylenediamine core, generation 1.0 solution;4,7,11,14,18,21-Hexaazatetracosanediamide, 95%;STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1;4,7,11,14,18,21-Hexaazatetracosanediamide, N1,N24-bis(2-aminoethyl)-4,21-bis[3-[(2-aminoethyl)amino]-3-oxopropyl]-11,14-bis[3-[[2-[bis[3-[(2-aminoethyl)amino]-3-oxopropyl]amino]ethyl]amino]-3-oxopropyl]-8,17-dioxo-;PAMAMG1.0 | | CAS: | 142986-44-5 | | MF: | C62H128N26O12 | | MW: | 1429.85 | | EINECS: | | | Product Categories: | Amino Surface Groups;Dendrimers;PAMAM Dendrimers | | Mol File: | 142986-44-5.mol |  |
| | STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1 Chemical Properties |
| Boiling point | 64.7 °C | | density | 0.82 g/mL at 25 °C | | refractive index | n20/D 1.362 | | Fp | 52 °F | | storage temp. | 2-8°C | | solubility | Water: Soluble | | pka | 9.23 | | form | 20 wt.% in methanol | | color | Colorless to light yellow | | InChIKey | QVWIZHOFYGKROL-UHFFFAOYSA-N | | SMILES | C(NCCN)(=O)CCN(CCC(NCCN)=O)CCNC(=O)CCN(CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)CCN(CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)CCC(=O)NCCN(CCC(NCCN)=O)CCC(NCCN)=O |
| Hazard Codes | F,T | | Risk Statements | 11-23/24/25-39/23/24/25-36/37/38 | | Safety Statements | 7-16-23-45-36/37-26 | | RIDADR | UN 1230 3/PG 2 | | WGK Germany | 3 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2
STOT SE 1
STOT SE 3 |
| | STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1 Usage And Synthesis |
| Uses | Starburst 1st Generation (PAMAM G1.0) is a Polyamidoamine (HY-164657; PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vitro. Starburst 1st Generation conjugated to di-n-dodecylamine and encapsulating 5-Fluorouracil (HY-90006) increase the solubility of 5-Fluorouracil and are cytotoxic to AGS gastric adenocarcinoma cells[1]. | | References | [1] Ender Sarigul, et al. Polyamidoamine Dendron-Bearing Lipids as Drug-Delivery Excipients. Molecules. 2022 Nov 13;27(22):7817. DOI:10.3390/molecules27227817
[2] TISHA C. KING HEIDEN . Developmental toxicity of low generation PAMAM dendrimers in zebrafish[J]. Toxicology and applied pharmacology, 2007, 225 1: Pages 70-79. DOI: 10.1016/j.taap.2007.07.009
[3] XIAOYE ZHANG. Preparation of PVDF/Hyperbranched-Nano-Palygorskite Composite Membrane for Efficient Removal of Heavy Metal Ions.[J]. Polymers, 2019, 11 1. DOI: 10.3390/polym11010156 |
| | STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1 Preparation Products And Raw materials |
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