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| | 1-Boc-3-(cyanomethyl)azetidine Basic information |
| Product Name: | 1-Boc-3-(cyanomethyl)azetidine | | Synonyms: | 3-(Cyanomethyl)-1-azetidinecarboxylic acid tert-butyl ester;1-Boc-3-(cyanomethyl)azetidine;1-Azetidinecarboxylic acid, 3-(cyanomethyl)-, 1,1-dimethylethyl ester;tert-butyl 3-(cyanomethyl)azetidine-1-carboxylate;2-(1-Boc-3-azetidinyl)acetonitrile;3-(Cyanomethyl)-1-azetidinecarboxylic acid 1,1-dimethylethyl ester | | CAS: | 142253-58-5 | | MF: | C10H16N2O2 | | MW: | 196.25 | | EINECS: | | | Product Categories: | | | Mol File: | 142253-58-5.mol |  |
| | 1-Boc-3-(cyanomethyl)azetidine Chemical Properties |
| Boiling point | 310.1±15.0 °C(Predicted) | | density | 1.089 | | storage temp. | 2-8°C | | pka | -2.33±0.40(Predicted) | | Appearance | White to off-white Solid |
| | 1-Boc-3-(cyanomethyl)azetidine Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of tert-butyl 3-(cyanomethyl)azetidine-1-carboxylate from tert-butyl 3-(cyanomethyl)azetidine-1-carboxylate was as follows: 2.60 g (13.9 mmol, 1.0 eq.) of tert-butyl 3-(cyanomethyl)azetidine-1-carboxylate was dissolved in 130 mL of methanol, 513 mg (0.48 mmol, 0.036 eq.) of 10% palladium/carbon catalyst (containing 50% water). The reaction mixture was stirred at room temperature for 2 hours under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford 2.63 g (13.3 mmol, 98% yield) of tert-butyl 3-(cyanomethyl)azetidine-1-carboxylate. The product was characterized by 1H NMR (400 MHz, chloroform-d) with the following chemical shifts δ [ppm]: 1.47 (s, 9H), 2.66 (d, J = 7.07 Hz, 2H), 2.83-2.93 (m, 1H), 3.71 (dd, J = 9.09, 5.05 Hz, 2H), 4.15 (t, J = 8.59 Hz, 2H). | | References | [1] Patent: WO2016/41925, 2016, A1. Location in patent: Page/Page column 254; 255 |
| | 1-Boc-3-(cyanomethyl)azetidine Preparation Products And Raw materials |
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