2-(1-naphthylmethylene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one

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2-(1-naphthylmethylene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one manufacturers
2-(1-naphthylmethylene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one Basic information
Product Name:2-(1-naphthylmethylene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
Synonyms:2-(1-naphthylmethylene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one;Thiazolo[3,2-a]benzimidazol-3(2H)-one, 2-(1-naphthalenylmethylene)-, (2Z)-;WAY-620520;(Z)-2-(Naphthalen-1-ylmethylene)benzo[4,5]imidazo[2,1-b]thiazol-3(2H)-one;Anti-inflammatory agent 42
CAS:877468-30-9
MF:C20H12N2OS
MW:328.39
EINECS:
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Mol File:877468-30-9.mol
2-(1-naphthylmethylene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one Structure
2-(1-naphthylmethylene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one Chemical Properties
Melting point 213-215 °C(Solv: acetic acid (64-19-7))
Boiling point 579.8±53.0 °C(Predicted)
density 1.37±0.1 g/cm3(Predicted)
pka1.19±0.20(Predicted)
form Solid
color Light yellow to brown
Safety Information
MSDS Information
2-(1-naphthylmethylene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one Usage And Synthesis
UsesAnti-inflammatory agent 42 (Compound 10j) is an anti-inflammatory agent. Anti-inflammatory agent 42 shows excellent inhibition on the expression of TNF-α and IL-6 in LPS (HY-D1056)-stimulated macrophages[1].
References[1] Hu J, et al. Synthesis and biological evaluation of novel thiazolidinone derivatives as potential anti-inflammatory agents. Eur J Med Chem. 2013 Jun;64:292-301. DOI:10.1016/j.ejmech.2013.04.010
2-(1-naphthylmethylene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one Preparation Products And Raw materials
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