Ramelteon-d5 manufacturers
- Ramelteon-D5
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- $3420.00
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2026-05-11
- CAS:1134159-63-9
- Purity:
- Supply Ability: 10g
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| | Ramelteon-d5 Basic information |
| Product Name: | Ramelteon-d5 | | Synonyms: | Ramelteon-d5;N-{2-[(8S)-1H,2H,6H,7H,8H-indeno[5,4-b]furan-8-yl]ethyl}(2H?)propanamide | | CAS: | 1134159-63-9 | | MF: | C16H21NO2 | | MW: | 259.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1134159-63-9.mol |  |
| | Ramelteon-d5 Chemical Properties |
| | Ramelteon-d5 Usage And Synthesis |
| Uses | Ramelteon-d5 is deuterium labeled Ramelteon. Ramelteon is a potent, highly selective, and orally active agonist of MT1/MT2 with Ki values of 14 and 112 pM, respectively. Ramelteon has the potential for the research of insomnia. Ramelteon consistently reduces sleep onset after long-term treatment, with no next-morning residual effects or rebound insomnia or withdrawal symptoms upon discontinuation[1][2]. | | IC 50 | MT2; MT1 | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Kato K, et al. Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 2005;48(2):301-310. DOI:10.1016/j.neuropharm.2004.09.007
[3] Mayer G, et al. Efficacy and safety of 6-month nightly ramelteon administration in adults with chronic primary insomnia. Sleep. 2009;32(3):351-360. DOI:10.1093/sleep/32.3.351
[4] Hirai K, et al. Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats. J Biol Rhythms. 2005;20(1):27-37. DOI:10.1177/0748730404269890
[5] Miyamoto M, et al. The sleep-promoting action of ramelteon (TAK-375) in freely moving cats. Sleep. 2004;27(7):1319-1325. DOI:10.1093/sleep/27.7.1319 |
| | Ramelteon-d5 Preparation Products And Raw materials |
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