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| | 9alpha,15S-dihydroxy-11-oxo-prosta-5z,12e-dien-1-oic acid Basic information |
| Product Name: | 9alpha,15S-dihydroxy-11-oxo-prosta-5z,12e-dien-1-oic acid | | Synonyms: | DELTA12-PROSTAGLANDIN D2;(5z,9-alpha,12e,15s)-9,15-dihydroxy-11-oxoprosta-5,12-dien-1-oicacid;9,15-dihydroxy-11-oxo-,(5z,9-alpha,12e,15s)-prosta-12-dien-1-oicacid;delta(sup12)-pgd2;delta(sup12)-prostaglandind2;(5Z,12E,15S)-9α,15-Dihydroxy-11-oxoprosta-5,12-dien-1-oic acid;Δ12-PGD2;Δ12-Prostaglandin D2 | | CAS: | 64072-89-5 | | MF: | C20H32O5 | | MW: | 352.47 | | EINECS: | | | Product Categories: | | | Mol File: | 64072-89-5.mol |  |
| | 9alpha,15S-dihydroxy-11-oxo-prosta-5z,12e-dien-1-oic acid Chemical Properties |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 2 mg/ml |
| | 9alpha,15S-dihydroxy-11-oxo-prosta-5z,12e-dien-1-oic acid Usage And Synthesis |
| Description | Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. Δ12-PGD2 is one of the initial chemical decomposition products of PGD2. Δ12-PGD2 is an intermediate in the pathway leading to Δ12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities. The metabolism of Δ12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins. | | Uses | Δ12(E)-Prostaglandin D2 is a derivative of Prostaglandin D2 (HY-101988). Prostaglandin D2 is one of the major Prostaglandins actively produced in the brain of various mammals[1]. | | References | [1] J Atsmon, et al. Formation of thiol conjugates of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 and delta 12(E)-prostaglandin D2. Biochemistry. 1990 Apr 17;29(15):3760-5. DOI:10.1021/bi00467a023 |
| | 9alpha,15S-dihydroxy-11-oxo-prosta-5z,12e-dien-1-oic acid Preparation Products And Raw materials |
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