| Company Name: |
BOC Sciences
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16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:GW 9578
CAS:247923-29-1
Purity:98% Package:1G;10G;100G Remarks:GW 9578 is a potent agonist of PPARα, which is highly selective for PPARα compared to PPARγ and PPARδ.
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:GW 9578
CAS:247923-29-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:GW 9578
CAS:247923-29-1
Purity:98% Package:1mg (solution); 10mg (solution); 5mg (solution); 500ug (solution) Remarks:Medbio
|
GW 9578 manufacturers
- GW 9578
-
- $980.00 / 10mg
-
2024-11-19
- CAS:247923-29-1
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | GW 9578 Basic information |
| Product Name: | GW 9578 | | Synonyms: | GW 9578 Exclusive;KYQNYMXQHLMADB-UHFFFAOYSA-N;GW 9578;Propanoic acid, 2-[[4-[2-[[[(2,4-difluorophenyl)amino]carbonyl]heptylamino]ethyl]phenyl]thio]-2-methyl- | | CAS: | 247923-29-1 | | MF: | C26H34F2N2O3S | | MW: | 492.6215664 | | EINECS: | | | Product Categories: | | | Mol File: | 247923-29-1.mol |  |
| | GW 9578 Chemical Properties |
| Boiling point | 641.7±55.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF:10.0(Max Conc. mg/mL);20.3(Max Conc. mM)
DMSO:10.0(Max Conc. mg/mL);20.3(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.61(Max Conc. mM)
Ethanol:2.5(Max Conc. mg/mL);5.07(Max Conc. mM) | | form | Liquid | | pka | 3.77±0.10(Predicted) | | color | Colorless to light yellow |
| | GW 9578 Usage And Synthesis |
| Uses | GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2]. | | IC 50 | mouse PPARα: 5 nM (EC50); h-PPARα: 50 nM (EC50) | | References | [1] P J Brown, et al. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. J Med Chem. 1999 Sep 23;42(19):3785-8. DOI:10.1021/jm9903601
[2] Alexandre Trifilieff, et al. PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect. Br J Pharmacol. 2003 May;139(1):163-71. DOI:10.1038/sj.bjp.0705232
[3] Dallas C Jones, et al. Nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is expressed in resting murine lymphocytes. The PPARalpha in T and B lymphocytes is both transactivation and transrepression competent. J Biol Chem. 2002 DOI:10.1074/jbc.M106908200 |
| | GW 9578 Preparation Products And Raw materials |
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