| Company Name: |
Wuhan ariel chemical Co., LTD.
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| Tel: |
18986259541 18986259541 |
| Email: |
sales@3stc.com |
| Products Intro: |
Product Name:4-aMino-5-Iodo-2-Methyl-pyridine
CAS:849353-19-1
Purity:97% Package:10g
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| | 4-AMINO-5-IODO-2-METHYLPYRIDINE Basic information |
| Product Name: | 4-AMINO-5-IODO-2-METHYLPYRIDINE | | Synonyms: | 4-AMINO-5-IODO-2-METHYLPYRIDINE;5-iodo-2-Methylpyridin-4-aMine;4-PyridinaMine, 5-iodo-2-Methyl-;5-Iodo-2-methyl-4-pyridinamine;5-Iodo-2-methylpyridin-4-ylamine;2-Methyl-4-amino-5-iodopyridine | | CAS: | 849353-19-1 | | MF: | C6H7IN2 | | MW: | 234.04 | | EINECS: | | | Product Categories: | | | Mol File: | 849353-19-1.mol |  |
| | 4-AMINO-5-IODO-2-METHYLPYRIDINE Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | Appearance | White to off-white Solid | | InChI | InChI=1S/C6H7IN2/c1-4-2-6(8)5(7)3-9-4/h2-3H,1H3,(H2,8,9) | | InChIKey | UJDOLPPZRSZZAS-UHFFFAOYSA-N | | SMILES | C1(C)=NC=C(I)C(N)=C1 |
| | 4-AMINO-5-IODO-2-METHYLPYRIDINE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 5-iodo-2-methylpyridin-4-amine (i55) from 2-methylpyridin-4-amine: to a solution of 2-methylpyridin-4-amine (5 g, 46 mmol) in water (25 mL) was added sodium carbonate (Na2CO3, 3.4 g, 32 mmol) and the reaction mixture was heated to reflux. Subsequently, potassium iodide (KI, 9.8 g, 59 mmol) and iodine (I2, 9.3 g, 36 mmol, dissolved in 50 mL of water) were added and the reaction was continued at reflux for 7 hours. Upon completion of the reaction, the reaction was quenched with sodium thiosulfate solution followed by extraction of the target compound with dichloromethane (DCM). The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting residue was purified by column chromatography on silica gel (100-200 mesh) using a hexane solution of 25% ethyl acetate as eluent to give the final target product 5-iodo-2-methylpyridin-4-amine (i55) (0.85 g, 8% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 2.20 (s, 3H), 6.00 (s, 2H), 6.49 (s, 1H), 8.22 (s, 1H). Mass spectrum (ESI) showed m/e(M + 1)+: 235. | | References | [1] Patent: WO2016/124508, 2016, A1. Location in patent: Page/Page column 68; 69 |
| | 4-AMINO-5-IODO-2-METHYLPYRIDINE Preparation Products And Raw materials |
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