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| | 3-(Benzyloxy)azetidine benzenesulfonate Basic information |
| Product Name: | 3-(Benzyloxy)azetidine benzenesulfonate | | Synonyms: | 3-(PhenylMethoxy)-azetidine HCl;3-(Benzyloxy)azetidine, HCl;3-(Phenylmethoxy)-azetidinehydrochloride;3-phenylmethoxyazetidine;3-(Benzyloxy)azetidine benzenesulfonic acid salt;3-(Benzyloxy)azetidine benzenesulfonate;3-(Benzyloxy)azetidine hydrochloride (1:1) | | CAS: | 897019-59-9 | | MF: | C10H14ClNO | | MW: | 199.68 | | EINECS: | | | Product Categories: | | | Mol File: | 897019-59-9.mol |  |
| | 3-(Benzyloxy)azetidine benzenesulfonate Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | White to off-white Solid | | InChI | InChI=1S/C10H13NO.ClH/c1-2-4-9(5-3-1)8-12-10-6-11-7-10;/h1-5,10-11H,6-8H2;1H | | InChIKey | BQTSSUSLZRYTQB-UHFFFAOYSA-N | | SMILES | O(C1CNC1)CC1C=CC=CC=1.Cl |
| | 3-(Benzyloxy)azetidine benzenesulfonate Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-(benzyloxy)azetidine-1-carboxylic acid tert-butyl ester from 3-(benzyloxy)azetidine-1-carboxylic acid: tert-butyl ester of 3-(benzyloxy)azetidine-1-carboxylic acid (1.0 g) was placed in a round-bottomed flask, methanol-HCl solution (15 ml, 20%) was added, and the reaction was stirred for 1 h at room temperature. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the solvent was evaporated under reduced pressure to give the crude product as a white solid. The crude product was washed several times with ethyl acetate and dried thoroughly to afford the target compound 3-(benzyloxy)azetidine hydrochloride as a white solid in 92% yield, which can be used for subsequent reactions without further purification. | | References | [1] Patent: WO2012/83246, 2012, A1. Location in patent: Page/Page column 46
[2] Patent: US9388164, 2016, B2. Location in patent: Page/Page column 74; 75
[3] Organic Letters, 2017, vol. 19, # 9, p. 2270 - 2273
[4] Patent: WO2017/202704, 2017, A1. Location in patent: Page/Page column 44; 45 |
| | 3-(Benzyloxy)azetidine benzenesulfonate Preparation Products And Raw materials |
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