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| | His-Ala-Asp-Ala-Val-Phe-Thr-Ala-Ala-Tyr-Ala-Arg-Leu-Arg-Lys-Gln-Met-Ala-Ala-Lys-Lys-Ala-Leu-Ala-Ala-Ile-Ala-Ala-NH2 Basic information |
| Product Name: | His-Ala-Asp-Ala-Val-Phe-Thr-Ala-Ala-Tyr-Ala-Arg-Leu-Arg-Lys-Gln-Met-Ala-Ala-Lys-Lys-Ala-Leu-Ala-Ala-Ile-Ala-Ala-NH2 | | Synonyms: | [ALA2,8,9,11,19,22,24,25,27,28]-VIP;L-Alaninamide, L-histidyl-L-alanyl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-alanyl-L-alanyl-L-tyrosyl-L-alanyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-alanyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-alanyl-L-alanyl-L-isoleucyl-L-alanyl-;His-A-D-A-Val-F-THR-A-Ala-Tyr-A-Arg-L-Arg-K-Gln-Me;His-Ala-Asp-Ala-Val-Phe-Thr-Ala-Ala-Tyr-Ala-Arg-Leu-Arg-Lys-Gln-Met-Ala-Ala-Lys-Lys-Ala-Leu-Ala-Ala-Ile-Ala-Ala-NH2 | | CAS: | 866552-34-3 | | MF: | C131H219N41O33S | | MW: | 2928.46 | | EINECS: | | | Product Categories: | | | Mol File: | 866552-34-3.mol |  |
| | His-Ala-Asp-Ala-Val-Phe-Thr-Ala-Ala-Tyr-Ala-Arg-Leu-Arg-Lys-Gln-Met-Ala-Ala-Lys-Lys-Ala-Leu-Ala-Ala-Ile-Ala-Ala-NH2 Chemical Properties |
| density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble to 2 mg/ml in 10% acetonitrile | | form | Powder | | Sequence | His-Ala-Asp-Ala-Val-Phe-Thr-Ala-Ala-Tyr-Ala-Arg-Leu-Arg-Lys-Gln-Met-Ala-Ala-Lys-Lys-Ala-Leu-Ala-Ala-Ile-Ala-Ala-NH2 |
| | His-Ala-Asp-Ala-Val-Phe-Thr-Ala-Ala-Tyr-Ala-Arg-Leu-Arg-Lys-Gln-Met-Ala-Ala-Lys-Lys-Ala-Leu-Ala-Ala-Ile-Ala-Ala-NH2 Usage And Synthesis |
| Description | Highly selective agonist for the VPAC1 receptor (IC50 values are ~ 15-13.2 and > 30000 nM for VPAC1 and VPAC2 receptors respectively). | | Uses | [Ala2,8,9,11,19,22,24,25,27,28]-VIP is an analog vasoactive intestinal polypeptide (VIP) with high affinity and selectivity for human VIP/pituitary adenylate cyclase-activating polypeptide 1 (hVPAC1). VIP is a widespread neurotransmitter[1]. | | References | [1] Hisato Igarashi, et al. Development of simplified vasoactive intestinal peptide analogs with receptor selectivity and stability for human vasoactive intestinal peptide/pituitary adenylate cyclase-activating polypeptide receptors. J Pharmacol Exp Ther. 2005 Oct;315(1):370-81. DOI:10.1124/jpet.105.088823 |
| | His-Ala-Asp-Ala-Val-Phe-Thr-Ala-Ala-Tyr-Ala-Arg-Leu-Arg-Lys-Gln-Met-Ala-Ala-Lys-Lys-Ala-Leu-Ala-Ala-Ile-Ala-Ala-NH2 Preparation Products And Raw materials |
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