(S)-2-(1-Carboxy-2-(4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl)ethylamino)benzoic acid methyl ester

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Company Name: TargetMol Chemicals Inc.  
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Company Name: TargetMol Chemicals Inc.  
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Email: marketing@targetmol.cn
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Tel: 13564774135
Email: marketing@targetmol.com

(S)-2-(1-Carboxy-2-(4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl)ethylamino)benzoic acid methyl ester manufacturers

  • GW7845
  • GW7845 pictures
  • $1520.00
  • 2026-07-27
  • CAS:196809-22-0
  • Purity:
  • Supply Ability: 10g
(S)-2-(1-Carboxy-2-(4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl)ethylamino)benzoic acid methyl ester Basic information
Product Name:(S)-2-(1-Carboxy-2-(4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl)ethylamino)benzoic acid methyl ester
Synonyms:L-Tyrosine, N-[2-(methoxycarbonyl)phenyl]-O-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-;GW 7845;GW7845;GW-7845;(2S)-2-[(2-Methoxycarbonylphenyl)amino]-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]propanoic acid;(S)-2-(1-Carboxy-2-(4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl)ethylamino)benzoic acid methyl ester
CAS:196809-22-0
MF:C29H28N2O6
MW:500.54
EINECS:
Product Categories:
Mol File:196809-22-0.mol
(S)-2-(1-Carboxy-2-(4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl)ethylamino)benzoic acid methyl ester Structure
(S)-2-(1-Carboxy-2-(4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl)ethylamino)benzoic acid methyl ester Chemical Properties
Melting point 140-141 °C
Boiling point 729.250±70.00 °C(Press: 760.00 Torr)(predicted)
density 1.269±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka3.906±0.10(predicted)
Safety Information
MSDS Information
(S)-2-(1-Carboxy-2-(4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl)ethylamino)benzoic acid methyl ester Usage And Synthesis
UsesGW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 μM by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells[1][2].
IC 50PPARγ; L-type calcium channel
References[1] Thomas J Heppner, et al. Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. Pharmacology. 2005 Jan;73(1):15-22. DOI:10.1159/000081070
[2] Jennifer J Schlezinger, et al. An L-tyrosine derivative and PPARgamma agonist, GW7845, activates a multifaceted caspase cascade in bone marrow B cells. Toxicol Sci. 2007 Jul;98(1):125-36. DOI:10.1093/toxsci/kfm071
[3] N Suh, et al. A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis. Cancer Res. 1999 Nov 15;59(22):5671-3. PMID:10582681
(S)-2-(1-Carboxy-2-(4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl)ethylamino)benzoic acid methyl ester Preparation Products And Raw materials
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