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| | 1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester, (3R)- Basic information |
| Product Name: | 1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester, (3R)- | | Synonyms: | (R)-1-Boc-3-piperidinecarboxaMide;(R)-1-Boc-3-(aMinocarbonyl)-piperidine;(R)-tert-Butyl 3-carbaMoylpiperidine-1-carboxylate;tert-Butyl (R)-3-carbamoylpiperidine-1-carboxylate;(R)-1-Boc-3-carbamoylpiperidine;tert-butyl (3R)-3-carbamoylpiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester, (3R)- | | CAS: | 915226-43-6 | | MF: | C11H20N2O3 | | MW: | 228.29 | | EINECS: | | | Product Categories: | | | Mol File: | 915226-43-6.mol |  |
| | 1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester, (3R)- Chemical Properties |
| Boiling point | 384.4±31.0 °C(Predicted) | | density | 1.123±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 16.41±0.20(Predicted) | | Appearance | White to off-white Solid | | Optical Rotation | Consistent with structure |
| | 1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester, (3R)- Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of tert-butyl (R)-3-carbamoylpiperidine-1-carboxylate from 3-piperidinecarboxamide and di-tert-butyl dicarbonate was as follows: to the reaction mixture obtained in Example 4 was added tetrahydrofuran (THF, 40 mL), followed by the addition of di-tert-butyl dicarbonate (37.2 g, 2.3 eq.). The pH of the reaction mixture was adjusted to 10.0 using sodium hydroxide (NaOH). the reaction mixture was stirred at room temperature for 1 hr, after which the precipitated crystals were collected by filtration to afford (R)-1 -(tert-butoxycarbonyl)piperidinamide as white crystals (15.6 g, yield: 93%). The crystals were analyzed using the method described in Example 3; the results showed an optical purity of 99.8% ee. 1H NMR (400 MHz, CDCl3) data were as follows: δ 5.36 (brs, 2H), 3.94-3.08 (m, 5H), 1.96-1.36 (m, 13H). | | References | [1] Patent: US2010/105917, 2010, A1. Location in patent: Page/Page column 16 |
| | 1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester, (3R)- Preparation Products And Raw materials |
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