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| | 9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one Basic information |
| Product Name: | 9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one | | Synonyms: | 9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one;9-Bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one;[1,2,4]Triazolo[1,5-c]quinazolin-5(6H)-one,9-bromo-;9-bromo-[1,2,4]triazolo[4,3-c]quinazolin-5(6H)-one;Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one | | CAS: | 882517-92-2 | | MF: | C9H5BrN4O | | MW: | 265.07 | | EINECS: | | | Product Categories: | | | Mol File: | 882517-92-2.mol | ![9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one Structure](CAS/GIF/882517-92-2.gif) |
| | 9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one Chemical Properties |
| density | 2.09 | | storage temp. | Sealed in dry,Room Temperature | | pka | 7.00±0.20(Predicted) |
| | 9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 9-bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one from (4-bromo-2-cyanophenyl)carbamic acid ethyl ester and formylhydrazine: to a solution of (4-bromo-2-cyanophenyl)carbamic acid ethyl ester (40.4 g, 150 mmol) in N-methyl pyrrolidone (NMP, 170 mL), was added formylhydrazine ( 10.0 g, 150 mmol). The reaction mixture was stirred at 160°C for 1.5 hours in a mild nitrogen atmosphere. Upon completion of the reaction, the mixture was cooled to below 100°C and water (340 mL) was slowly added. The resulting slurry was further cooled to 25°C and stirred continuously for 15 minutes. The precipitated solid was collected by filtration and washed sequentially with water and 2-propanol. Finally, the product was dried under vacuum to afford 9-bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one (32.4 g, 81% yield) as a light yellow solid. Mass spectrometry (MS) analysis result: m/e = 264.9/267.0 (M + H+). | | References | [1] Patent: US2006/84642, 2006, A1. Location in patent: Page/Page column 9
[2] Patent: US2006/84801, 2006, A1. Location in patent: Page/Page column 12
[3] Patent: US2006/79507, 2006, A1. Location in patent: Page/Page column 18
[4] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 20, p. 5940 - 5944 |
| | 9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one Preparation Products And Raw materials |
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