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| | 1-Phenyl-1H-imidazole-4-carboxylic acid Basic information |
| | 1-Phenyl-1H-imidazole-4-carboxylic acid Chemical Properties |
| Boiling point | 424.5±18.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 1.48±0.10(Predicted) | | Appearance | White to off-white Solid |
| | 1-Phenyl-1H-imidazole-4-carboxylic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 1-phenyl-1H-imidazole-4-carboxylic acid from methyl 1-phenyl-1H-imidazole-4-carboxylate: LiOH-H2O (143 mg, 3.4 mmol) was added to a stirred methyl 1-phenyl-1H-imidazole-4-carboxylic acid (231 mg, 1.1 mmol) solution in a mixture of THF (3 mL), MeOH (1 mL), and H2O ( 1 mL) in mixed solvents and continued stirring for 3 hours at room temperature. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. Subsequently, cold water was added and acidified with 10% aqueous HCl and the precipitated solid was collected to give 180 mg (83.7% yield) of 1-phenyl-1H-imidazole-4-carboxylic acid. | | References | [1] Patent: US2009/239810, 2009, A1. Location in patent: Page/Page column 81
[2] Patent: US2010/160323, 2010, A1. Location in patent: Page/Page column 24
[3] Patent: WO2017/103614, 2017, A1. Location in patent: Page/Page column 67 |
| | 1-Phenyl-1H-imidazole-4-carboxylic acid Preparation Products And Raw materials |
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