OAC2
| 中文名称 | OAC2 |
|---|---|
| 中文同义词 | N-(1H-吲哚-5-基)苯甲酰胺, >98%;N-(1H-吲哚-5-基)苯甲酰胺;化合物OAC2;优选]OAC2;OAC-2,OCT4激活剂;化合物OAC2,10 MM DMSO 溶液;OAC2(OAC-2) |CAS 6019-39-2;OAC2 ,S5915 |
| 英文名称 | 5-benzoylaminoindole |
| 英文同义词 | 5-benzoylaminoindole;N-(1H-Indol-5-yl)benzaMide;CS-2128;OAC-2;OAC 2;OAC2?, >98%;Benzamide, N-1H-indol-5-yl-;OAC2, 10 mM in DMSO;OAC2 ，S5915 |
| CAS号 | 6019-39-2 |
| 分子式 | C15H12N2O |
| 分子量 | 236.27 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;Inhibitors;Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 6019-39-2.mol |
| 结构式 |  |
OAC2 性质
| 熔点 | 165 - 167°C |
|---|---|
| 沸点 | 364.3±15.0 °C(Predicted) |
| 密度 | 1.307±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.99±0.43(Predicted) |
| 颜色 | 淡黄色低 |
| InChI | 1S/C15H12N2O/c18-15(11-4-2-1-3-5-11)17-13-6-7-14-12(10-13)8-9-16-14/h1-10,16H,(H,17,18) |
| InChIKey | JCAFGYWSIWYMOX-UHFFFAOYSA-N |
| SMILES | O=C(NC1=CC=C(NC=C2)C2=C1)C3=CC=CC=C3 |
| Target | Value |
|
OCT4
() |
Octamer-binding transcription factor 4 (Oct4) is a master regulator of the induction and maintenance of cellular pluripotency, and has crucial roles in early stages of differentiation. It is the only factor that cannot be substituted by other members of the same protein family to induce pluripotency. Oct4 has been shown to be an essential regulator of embryonic stem cell (ESC) pluripotency and key to the reprogramming process. OAC2 is a structural analog of OAC1. OAC2 activates both Oct4 and Nanog reporters to a similar extent as OAC1. OAC1 and its two structural analogs OAC2 and OAC3 enhances reprogramming efficiency fourfold, up to as high as 2.75%, and accelerates the appearance of iPSC colonies 3 to 4 d when used in combination with the four reprogramming factors, Oct4, Sox2, Klf4, and c-Myc.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 经口 |