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| | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid Basic information |
| | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid Chemical Properties |
| Melting point | >271oC (dec.) | | Boiling point | 478.3±45.0 °C(Predicted) | | density | 1.745±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | pka | 5.75±0.20(Predicted) | | form | Solid | | color | White to Pale Beige |
| | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid Usage And Synthesis |
| Uses | Moxifloxacin (M745000) impurity. | | Synthesis | About 500 mL of DMSO filtrate from the nucleophilic substitution reaction was transferred to a 1000 mL reactor and anhydrous calcium chloride (about 33 g) was added under stirring conditions. The reaction mixture was cooled with stirring to 0-5 °C and maintained in this temperature range for 30 minutes. Subsequently, the pH was adjusted to 4 with a 15% aqueous hydrochloric acid solution, the temperature was maintained between 0-5°C, and stirring was continued for 3 hours. Upon completion of the reaction, the precipitated product was collected by filtration, washed well with acetone and then dried. A dry 1-cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (about 35 g) with a purity of more than 90% was finally obtained. | | References | [1] Patent: WO2006/4561, 2006, A1. Location in patent: Page/Page column title page; 4; 12-13
[2] Patent: WO2008/62379, 2008, A2. Location in patent: Page/Page column 37
[3] Patent: US2010/222302, 2010, A1. Location in patent: Page/Page column 21
[4] Patent: WO2007/17828, 2007, A2. Location in patent: Page/Page column 54 |
| | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid Preparation Products And Raw materials |
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