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Ipsapirone manufacturers
- Ipsapirone
-
- $30.00
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2026-08-04
- CAS:95847-70-4
- Purity: 99.51%
- Supply Ability: 10g
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| | Ipsapirone Basic information |
| Product Name: | Ipsapirone | | Synonyms: | IPSAPIRONE;2-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-1,2-BENZISOTHIAZOL-3(2H)-ONE-1,1-DIOXIDE;1,2-benzisothiazol-3(2h)-one,2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-,1,;Isapirone;2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide;Benzeneethanamine,5-chloro-α-methyl-;1,2-Benzisothiazol-3(2H)-one, 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, 1,1-dioxide;Ipsapirone, 10 mM in DMSO | | CAS: | 95847-70-4 | | MF: | C19H23N5O3S | | MW: | 401.48 | | EINECS: | | | Product Categories: | Serotonin receptor | | Mol File: | 95847-70-4.mol |  |
| | Ipsapirone Chemical Properties |
| Melting point | 137-138° | | Boiling point | 629.8±65.0 °C(Predicted) | | density | 1.345±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | Soluble to 10 mM in DMSO | | form | Powder | | pka | 7.69±0.10(Predicted) | | color | White to off-white |
| | Ipsapirone Usage And Synthesis |
| Uses | Anti-anxiety agent
. | | Uses | Ipsapirone is a selective SR-1A agonist. | | Definition | ChEBI: 1,1-dioxo-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzothiazol-3-one is a N-arylpiperazine. | | Biological Activity | Selective 5-HT 1A receptor agonist (K i = 10 nM). Anxiolytic in vivo . | | in vivo | Ipsapirone inhibits induced by 8-OH-DPAT and 5-methoxydimethyltryptamine (agonists of 5-HT1A receptors) behavioural effects (flat body posture and forepaw treading) in normal and reserpinized rats[1].
Ipsapirone (2.5-80 mg/kg), given alone to rats induces a slight flattening of body posture (~ 1 point at the highest dose) and a mild hind limb abduction observed at doses 2.5-80 mg/kg. Ipsapirone given alone at low doses (2.5-10 mg/kg i.p.) does not significantly change the body temperature in rats and mice, but decreased it in both those species at high doses (35 mg/kg i.p.) by ca. 2-2.5℃[1].
| Animal Model: | Male Albino-Swiss mice (18-24 g) and male Wistar rats (160-200 g)[1].
| | Dosage: | 5 and 10 mg/kg. | | Administration: | IP 30 min before 8-OH-DPAT and 5-MeODMT injections. | | Result: | Behavioural responses (flat body posture, forepaw treading) to 8-OH-DPAT (5 mg/kg s.c.) in rats were antagonized by Ipsapirone (5 and 10 mg/kg i.p.). |
| | IC 50 | 5-HT1A Receptor | | storage | Room temperature |
| | Ipsapirone Preparation Products And Raw materials |
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