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| | β-Gal-NONOate Basic information |
| Product Name: | β-Gal-NONOate | | Synonyms: | β-Gal-NONOate;(E)-oxido-pyrrolidin-1-yl-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyiminoazanium;β-D-Galactopyranose, 1-O-[2-oxido-2-(1-pyrrolidinyl)diazenyl]-;-Gal-nonoate | | CAS: | 357192-77-9 | | MF: | C10H19N3O7 | | MW: | 293.27 | | EINECS: | | | Product Categories: | | | Mol File: | 357192-77-9.mol |  |
| | β-Gal-NONOate Chemical Properties |
| Boiling point | 525.043±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.807±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): 2 mg/ml | | form | A crystalline solid | | pka | 14.477±0.10(predicted) |
| | β-Gal-NONOate Usage And Synthesis |
| Description | β-Gal-NONOate is a nitric oxide (NO) donor which releases NO following activation by β-galactosidase.1 β-Gal-NONOate is stable in aqueous solution at neutral and acidic pH for several hours, exhibits good water solubility, and is able to cross the cell membrane. Following enzymatic hydrolysis, β-Gal-NONOate decomposes with a half-life of six minutes at pH 5.6.1 β-Gal-NONOate is cytotoxic to a number of cancer cell-lines and exhibits high bactericidal activity against E. coli transformed with the β-galactosidase gene.1,2 | | Uses | Beta-gal-nonoate is a β-galactosidase dependent nitric oxide (NO) donor that releases NO once activated by β-galactosidase. β-Gal-NONOate has bactericidal activity and can be used as a bactericide [1]. | | References | 1. Wu, X., Tang, X., Xian, M., et al. Glycosylated diazeniumdiolates: A novel class of enzyme-activated nitric oxide donors Tetrahedron Lett. 42(23),3779-3782(2001).
2. Chen, C., Shi, Y.Q., Song, J., et al. Delivery of nitric oxide released from β-Gal-NONOate activation by β-galactosidase and its activity against Escherichia coli Biol. Pharm. Bull. 29(6),1239-1241(2006). |
| | β-Gal-NONOate Preparation Products And Raw materials |
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