Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]-

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Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- Suppliers list
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Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- manufacturers

  • PF-00446687
  • PF-00446687 pictures
  • $297.00
  • 2026-05-11
  • CAS:862281-92-3
  • Purity:
  • Supply Ability: 10g
Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- Basic information
Product Name:Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]-
Synonyms:Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]-;[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[(3S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl]methanone;PF00446687,PF 00446687
CAS:862281-92-3
MF:C28H36F2N2O2
MW:470.59
EINECS:
Product Categories:
Mol File:862281-92-3.mol
Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- Structure
Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- Chemical Properties
Boiling point 571.9±50.0 °C(Predicted)
density 1.167±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 62.5 mg/mL (132.81 mM)
form Solid
pka13.86±0.60(Predicted)
color White to off-white
Safety Information
MSDS Information
Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- Usage And Synthesis
UsesPF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12±1 nM[1]. Pf-446687 is brain penetrant[2].
in vivo

Pf-446687 is highly selective for MC4R and is both brain penetrant and stable in vivo. Peripheral administration of the brain penetrant MC3/4R receptor peptide agonist, Melanotan II (MTII), and the highly selective, small molecule MC4R agonist, Pf-446687, enhances partner preference formation in the prairie vole, but not in the non-monogamous meadow vole[2].

IC 50MC4R
References[1] Lansdell MI, et al. Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans. J Med Chem. 2010 Apr 22;53(8):3183-97. DOI:10.1021/jm9017866
[2] Modi ME, et al. Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul;40(8):1856-65. DOI:10.1038/npp.2015.35
Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- Preparation Products And Raw materials
Tag:Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]-(862281-92-3) Related Product Information
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