SOBETIROME
| 中文名称 | SOBETIROME |
|---|---|
| 中文同义词 | 化合物SOBETIROME;2-(4-(4-羟基-3-异丙基苄基)-3,5-二甲基苯氧基)乙酸;索贝罗姆;化合物SOBETIROME,10 MM DMSO 溶液;GC-1 spg细胞 (小鼠精原细胞) (种属鉴定正确);GC-1 spg细胞 (小鼠精原细胞) (种属鉴定正确)CL-0600;Olfactomedin-4/OLFM4 多克隆抗体(Capture/Detector)-AN000590P;重组人 OLFM4蛋白(His标签)-PDMH100200 |
| 英文名称 | QRX 431 |
| 英文同义词 | GC-1; QRX-431;2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid;GC-1 (Sobetirome);Anti-solute carrier family 25 (mitochondrial carrier: glutamate), member 22;[4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid;QRX 431;[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]acetic acid;GC 1 (pharmaceutical) |
| CAS号 | 211110-63-3 |
| 分子式 | C20H24O4 |
| 分子量 | 328.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 211110-63-3.mol |
| 结构式 |  |
SOBETIROME 性质
| 熔点 | 122 - 124°C |
|---|---|
| 沸点 | 510.2±45.0 °C(Predicted) |
| 密度 | 1.152±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | DMSO：可溶10mg/mL，澄清 |
| 酸度系数(pKa) | 3.22±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 生物来源 | rabbit |
| InChI | InChI=1S/C20H24O4/c1-12(2)17-9-15(5-6-19(17)21)10-18-13(3)7-16(8-14(18)4)24-11-20(22)23/h5-9,12,21H,10-11H2,1-4H3,(H,22,23) |
| InChIKey | QNAZTOHXCZPOSA-UHFFFAOYSA-N |
| SMILES | C(O)(=O)COC1=CC(C)=C(CC2=CC=C(O)C(C(C)C)=C2)C(C)=C1 |
Sobetirome (GC-1) 是一种甲状腺激素受体 β (TRβ) 激动剂，Sobetirome可选择性结合到TRβ-1，EC50 为 0.16 μM。
EC50: 0.16 μM (TRβ-1), 0.58 μM (TRα-1)
Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)- and liver uptake-selective agonist. Sobetirome (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice. Treatment with 10× Sobetirome (GC-1) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20× Sobetirome (GC-1) induces a decrease in fat mass of 20% (1.3 g).
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-14823R | SOBETIROME Sobetirome (Standard) | 211110-63-3 | 1 mg | 1000元 |
| 2026/06/05 | HY-14823R | SOBETIROME Sobetirome (Standard) | 211110-63-3 | 5 mg | 2400元 |