JW-55
| 中文名称 | JW-55 |
|---|---|
| 中文同义词 | N-[4-[[[[四氢-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺;N-[4-[[[[四氢-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺(JW55);Β-CATENIN抑制剂(JW 55);N-(4-((4-(4-甲氧基苯基)四氢-2H-吡喃-4-基)甲基氨基甲酰基)苯基)呋喃-2-甲酰胺;N-(4-(((4-(4-甲氧基苯基)四氢-2H-吡喃-4-基)甲基)氨甲酰)苯基)呋喃-2-甲酰胺;JW55,罐锚酶抑制剂;化合物 JW55;N-(4-(((4-(4-甲氧基苯基)四氢-2H-吡喃-4-基)甲基)氨甲酰)苯基)呋喃-2-甲酰胺/Β-CATENIN抑制剂(JW 55) |
| 英文名称 | JW55 |
| 英文同义词 | JW55;N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide;N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE;N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide;JW55 N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide;JW 55, >=98%;N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid;Tankyrase1/2 Inhibitor IV, JW55 |
| CAS号 | 664993-53-7 |
| 分子式 | C25H26N2O5 |
| 分子量 | 434.48 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;小分子抑制剂;小分子抑制剂，天然产物;Inhibitors;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 664993-53-7.mol |
| 结构式 |  |
JW-55 性质
| 沸点 | 572.6±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.235±0.06 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,2-8°C |
| 溶解度 | DMSO：可溶15mg/mL，澄清 |
| 酸度系数(pKa) | 12.41±0.70(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| InChIKey | ZJZWZIXSGNFWQQ-UHFFFAOYSA-N |
| SMILES | O1C=CC=C1C(NC1=CC=C(C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)=O)C=C1)=O |
JW55是一种有效的、选择性经典Wnt信号通路抑制剂，通过抑制TNKS1/2的PARP区域发挥作用。
| Target | Value |
|
Wnt
() |
JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC 50 value of 470 nM. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells.
JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication in Xenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice.
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-13968 | JW 55 | 664993-53-7 | 5 mg | 248元 |
| 2025/12/22 | HY-13968 | JW-55 JW 55 | 664993-53-7 | 10mM * 1mLin DMSO | 280元 |