- A-967079
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- $50.00
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2026-07-17
- CAS:1170613-55-4
- Purity: 99.92%
- Supply Ability: 10g
- A 967079
-
-
2025-03-16
- CAS:1170613-55-4
- Min. Order: 10mg
- Purity: 99
- Supply Ability: 20G
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| | A 967079 Basic information |
| Product Name: | A 967079 | | Synonyms: | A 967079;(1E,3E)-1-(4-Fluorophenyl)-2-Methyl-1-penten-3-one oxiMe;(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime;1-Penten-3-one, 1-(4-fluorophenyl)-2-methyl-, oxime, (1E,3E)-;TRP Channel,inhibit,Transient receptor potential channels,A 967079,Inhibitor,A-967079,A967079;A-967079, TRPA1 receptor antagonist;A-967079, 10 mM in DMSO | | CAS: | 1170613-55-4 | | MF: | C12H14FNO | | MW: | 207.24 | | EINECS: | | | Product Categories: | Aliphatics, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 1170613-55-4.mol |  |
| | A 967079 Chemical Properties |
| Boiling point | 324.4±34.0 °C(Predicted) | | density | 1.03±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | 2-8°C | | solubility | DMSO: ≥12mg/mL | | pka | 12.23±0.40(Predicted) | | form | powder | | color | white to tan | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months | | InChI | InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+ | | InChIKey | HKROEBDHHKMNBZ-CHBKHGQFSA-N | | SMILES | C(/C1=CC=C(F)C=C1)=C(/C)\C(=N\O)\CC |
| WGK Germany | 3 | | HS Code | 2928009090 | | Storage Class | 11 - Combustible Solids |
| | A 967079 Usage And Synthesis |
| Description | A-967079 (1170613-55-4) is a TRPA1 blocker. Active in rat models.1 Cell permeable | | Uses | (1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain. | | Uses | A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel. | | General Description | A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury. | | Biochem/physiol Actions | A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation. | | storage | +4°C | | Advantages | (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime (A-967079) has shown impressive efficacy as an antagonist to TRPA1 and has multiple advantages over other compounds, including high selectivity, potency, and oral bioavailability. A-967079 has IC50 values of 67 and 289 nM for human and rat TRPA1 receptors, respectively. It displays 1000-fold selectivity for TRPA1 over other TRP channels, and >150-fold selectivity for over 75 other ion channels, enzymes and G-protein-coupled receptors. Oral administration of A-967079 in rats produced robust bioavailability and analgesic efficacy for TIH-induced pain response (i.e., sneezing, tearing, coughing, etc.) and osteoarthritic pain. Intravenous injection of A-967079 has shown to decrease the reactive gas response of wide dynamic range neurons (i.e., a second-order neuron that responds to more than one type of stimulus) and pain specific-neurons. Aditionally, A-967079 produces no known locomotor or cardiovascular effects, a common side effect of other TRP antagonists[2]. | | References |
[1] McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats; Mol. Pain, 6 14.
[2] Obed A. Gyamfi . “Analysis of TRPA1 antagonist, A-967079, in plasma using high-performance liquid chromatography tandem mass-spectrometry.” Journal of Pharmaceutical Analysis 10 2 (2020): Pages 157-163.
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| | A 967079 Preparation Products And Raw materials |
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