- SAR125844
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- $1.00
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2019-09-06
- CAS:1116743-46-4
- Min. Order: 1KG
- Purity: 95%~99%
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| | SAR125844 Basic information |
| Product Name: | SAR125844 | | Synonyms: | SAR125884;SAR125884 hydrochlorid (1116743-46-4(free base));SAR125844; SAR 125844; SAR-125844;SAR125844;1-[6-[[6-(4-Fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]-3-[2-(morpholin-4-yl)ethyl]urea;SAR125844 /SAR-125844;Urea, N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N'-[2-(4-morpholinyl)ethyl]-;1-(6-((6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea | | CAS: | 1116743-46-4 | | MF: | C25H23FN8O2S2 | | MW: | 550.63 | | EINECS: | | | Product Categories: | | | Mol File: | 1116743-46-4.mol |  |
| | SAR125844 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 45 mg/mL (81.72 mM) | | form | Solid | | color | Light yellow to yellow |
| | SAR125844 Usage And Synthesis |
| Uses | SAR125844 is a potent, selective, and ATP-competitive MET kinase inhibitor with the value of IC50 is 4.2 nM and Ki is 2.8 nM. SAR125844 has antitumor activity and can be used for the research of cancer[1][2][3]. | | Biological Activity | SAR125844 is a potent and highly selective Met (c-Met) kinase inhibitor with nanomolar activity against wild-type Met (c-Met) kinase (IC50=4.2 nM), against H1094Y, Y1235D, M1250T, The IC50s of the L1195V and D1228H mutants were 0.22, 1.7, 6.5, 65 and 81 nM, respectively. | | in vitro | SAR125844 is an ATP-competitive and reversible inhibitor. SAR125844 has moderate activity against RON, a homolog that is structurally similar to MET, and SAR125844 inhibits RON with an IC50 of approximately 740 nM. SAR125844 is more than 100-fold more selective for MET kinase than for RON. | | in vivo | In a pharmacokinetic study in mice, the oral bioavailability of SAR125844 was low, approximately 2%. Its Caco-2 permeability is moderate. In female SCID mice bearing xenograft tumors (inoculated with the MET-expanded Hs 746T human gastric tumor cell line), a single intravenous injection of 20 mg/kg of SAR125844 resulted in a plasma exposure of 6190 h ng/kg mL, clearance CL = 3.1 L/h/kg, large volume of distribution (Vss = 4.2 L/kg). | | IC 50 | c-Met | | References | [1] Egile C, et al. The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancer [J]. Molecular cancer therapeutics, 2015, 14(2): 384-394. DOI:10.1158/1535-7163.MCT-14-0428
[2] Angevin E, et al. A first-in-human phase I study of SAR125844, a selective MET tyrosine kinase inhibitor, in patients with advanced solid tumours with MET amplification [J]. European Journal of Cancer, 2017, 87: 131-139. DOI:10.1016/j.ejca.2017.10.016
[3] Ugolini A, et al. Discovery and pharmacokinetic and pharmacological properties of the potent and selective MET kinase inhibitor 1-{6-[6-(4-fluorophenyl)-[1, 2, 4] triazolo [4, 3-b] pyridazin-3-ylsulfanyl] benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl) urea (SAR125844) [J]. 2016. DOI:10.1021/acs.jmedchem.6b00280
[4] Egile C, et al. The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancer. Mol Cancer Ther. 2015 Feb;14(2):384-94. DOI:10.1158/1535-7163.MCT-14-0428 |
| | SAR125844 Preparation Products And Raw materials |
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