| Company Name: |
Artis Biotech Co. Ltd.
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| Tel: |
18108108965 18108108965 |
| Email: |
sales@artisbio.com |
| Products Intro: |
Product Name:Bosutinib D8
CAS:2733145-45-2
Purity:98%HPLC Package:1mg;5mg;10mg;50mg
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| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
|
| Tel: |
13636370518 |
| Email: |
shyysw007@163.com |
| Products Intro: |
Product Name:Bosutinib D8
CAS:2733145-45-2
Purity:>=98 atom% D,>=98% Package:1mg Remarks:B68308
|
| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 400-920-5774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:Bosutinib-d8
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
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| | Bosutinib-d8 Basic information |
| Product Name: | Bosutinib-d8 | | Synonyms: | Bosutinib-d8;4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)propoxy)quinoline-3-carbonitrile;4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-{3-[4-methyl(2,2,3,3,5,5,6,6-2H?)piperazin-1-yl]propoxy}quinoline-3-carbonitrile;D8-Bosutinib | | CAS: | 2733145-45-2 | | MF: | C26H29Cl2N5O3 | | MW: | 530.44616 | | EINECS: | | | Product Categories: | | | Mol File: | 2733145-45-2.mol |  |
| | Bosutinib-d8 Chemical Properties |
| solubility | DMSO: Slightly Soluble
Methanol: Slightly Soluble | | form | Solid | | color | White to off-white |
| | Bosutinib-d8 Usage And Synthesis |
| Chemical Properties | Pale Yellow Solid | | Uses | A novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. This is the labeled analog. | | References | [1] DIANE H. BOSCHELLI. Optimization of 4-Phenylamino-3-quinolinecarbonitriles as Potent Inhibitors of Src Kinase Activity[J]. Journal of Medicinal Chemistry, 2001, 44 23: 3965-3977. DOI: 10.1021/jm0102250
[2] JENNIFER M GOLAS. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.[J]. Cancer research, 2003, 63 2: 375-381.
[3] L L REMSING RIX. Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells[J]. Leukemia, 2008, 23 3: 477-485. DOI: 10.1038/leu.2008.334 |
| | Bosutinib-d8 Preparation Products And Raw materials |
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