| Company Name: |
MedChemexpress LLC
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021-58955995 |
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sales@medchemexpress.cn |
| Products Intro: |
Product Name:Tenofovir (maleate)
CAS:1236287-04-9
Purity:>98% Package:465RMB/5mg
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| Company Name: |
LETOPHARM LIMITED
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| Tel: |
+86-21-5821 5861 |
| Email: |
sales@letopharm.com |
| Products Intro: |
Product Name:Tenofovir (Maleate)
CAS:1236287-04-9
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Email: |
eric_feng1954@126.com |
| Products Intro: |
Product Name:Tenofovir (Maleate)
CAS:1236287-04-9
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
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Tenofovir (Maleate) manufacturers
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| | Tenofovir (Maleate) Basic information |
| | Tenofovir (Maleate) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Powder |
| | Tenofovir (Maleate) Usage And Synthesis |
| Uses | Tenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B. | | Biological Activity | tenofovir maleate is an inhibitor of reverse transcriptase used for the treatment of the human immunodeficiency virus 1(hiv-1) and hepatitis b [1].tenofovir maleate is an antiviral pro-drug and the class of nucleoside reverse transcriptase inhibitor. in addition, tenofovir maleate has been reported to have a dependent relation between intracellular the drug concentrations and prevent function of hiv-1infection with ec50 values of 29 fmol/106, 40 fmol/106 , 77 fmol/106 and 411 fmol/106 cells for inoculum size 1, 5, 20 and 100 respectively. and the ec50 values of tenofovir maleate are 267 fmol/106, 348 fmol/106, 640 fmol/106 and 2866 fmol/106 cells for virus inoculums size 1, 5, 20 and 100, respectively [1]. | | in vivo | Tenofovir Disoproxil Fumarate (20, 50, 140, or 300mg/kg) administered to BLT mice, shows dose dependent activity during vaginal HIV challenge in BLT humanized mice. Tenofovir Disoproxil Fumarate (50, 140, 300mg/kg) significantly reduces HIV transmission in BLT mice[3]. Tenofovir Disoproxil Fumarate (0.5, 1.5, or 5.0 mg/kg/day, p.o.) induces a dose-dependent decline in serum viremia in woodchucks chronically infected with WHV. Tenofovir Disoproxil Fumarate administration is safe and effective in the woodchuck model of chronic HBV infection[4]. | | IC 50 | HIV-1 | | references | [1] duwal s1, schütte c, von kleist m.pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against hiv-1 infection. plos one. 2012;7(7):e40382. doi: 10.1371/journal.pone.0040382. epub 2012 jul 11. |
| | Tenofovir (Maleate) Preparation Products And Raw materials |
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