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| | N-Desmethyltamoxifen, hydrochloride Basic information |
| Product Name: | N-Desmethyltamoxifen, hydrochloride | | Synonyms: | (Z)-2-[4-(1,2-DIPHENYL-1-BUTENYL)PHENOXY]-N-METHYL-ETHANAMINE;Tamoxifen EP Impurity F;2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamine HCl;N-DESMETHYL TAMOXIFEN HCL;N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE;2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin;2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin;cis-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-n-methylethylamine | | CAS: | 31750-48-8 | | MF: | C25H27NO | | MW: | 357.49 | | EINECS: | | | Product Categories: | | | Mol File: | 31750-48-8.mol |  |
| | N-Desmethyltamoxifen, hydrochloride Chemical Properties |
| Boiling point | 485.8±33.0 °C(Predicted) | | density | 1.047±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 72 mg/mL (201.40 mM);Ethanol: 36 mg/mL (100.70 mM) | | pka | 9.38±0.10(Predicted) | | Water Solubility | Water: Insoluble |
| | N-Desmethyltamoxifen, hydrochloride Usage And Synthesis |
| Definition | ChEBI: N-Desmethyltamoxifen is a stilbenoid. | | Biological Activity | N-Desmethyltamoxifen is the main metabolite of Tamoxifen in the human body. N-Desmethyltamoxifen, a weaker antiestrogen, is a protein kinase C (PKC) inhibitor ten times stronger than Tamoxifen. It is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis and sphingosine phosphorylation. | | in vitro | N-desmethyltamoxifen (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
It inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen. Cell Viability Assay | Cell Line: | MCF 7 human mammary carcinoma cells | | Concentration: | 1.5, 2.5, 5, 7.5, 10 μM | td> | Incubation Time: | 114 hours | | Result: | Inhibits growth of MCF 7 human mammary carcinoma cells | | | target | | PKC | Estrogen Receptor | < /table>
| | N-Desmethyltamoxifen, hydrochloride Preparation Products And Raw materials |
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Tag:N-Desmethyltamoxifen, hydrochloride(31750-48-8)
Related Product Information
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Tamoxifen
N-Desmethyl Tamoxifen Hydrochloride
desdimethyltamoxifen
2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine
Toremifene Impurity 4
Tamoxifen Citrate EP Impurity C
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