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| | 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Basic information |
| | 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Chemical Properties |
| Boiling point | 423.3±45.0 °C(Predicted) | | density | 1.437±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | -0.34±0.20(Predicted) | | Appearance | White to light yellow Solid |
| | 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Usage And Synthesis |
| Synthesis | Example A8: Example A7 (0.750 g, 2.87 mmol) was suspended in 3 M NaOH aqueous solution (7.5 mL, 22.50 mmol) and heated to reflux at 100 °C for 1.5 hrs. Upon completion of the reaction, the mixture was cooled to room temperature and slowly acidified to pH 2 with 3 M aqueous HCl. The precipitated white solid was collected by vacuum filtration and washed with deionized water and dried to afford 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid (669 mg, 100% yield). The product was analyzed by mass spectrometry (ESI), m/z: 234.1 ([M + H]+). | | References | [1] Patent: WO2014/145004, 2014, A1. Location in patent: Paragraph 0111
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 17, p. 5330 - 5341
[3] Patent: WO2009/94417, 2009, A1. Location in patent: Page/Page column 28; 35-36
[4] Patent: WO2014/713, 2014, A1. Location in patent: Page/Page column 38 |
| | 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Preparation Products And Raw materials |
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