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1-631-485-4226; 16314854226 |
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Kif15-IN-1 manufacturers
- Kif15-IN-1
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- $499.00
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2026-08-18
- CAS:672926-32-8
- Purity: 99.39%
- Supply Ability: 10g
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| | Kif15-IN-1 Basic information |
| Product Name: | Kif15-IN-1 | | Synonyms: | Kif15-IN-1;2-[[(2S)-2-(1,4-Dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester;Kif15 inhibitor 1;5-Thiazolecarboxylic acid, 2-[[(2S)-2-(1,4-dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-, ethyl ester;Kif-15-IN-1,Kif15IN1,Kif15 IN 1;Ethyl (S)-2-(2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-3-methylbutanamido)-4-methylthiazole-5-carboxylate | | CAS: | 672926-32-8 | | MF: | C20H22N4O5S | | MW: | 430.48 | | EINECS: | | | Product Categories: | | | Mol File: | 672926-32-8.mol |  |
| | Kif15-IN-1 Chemical Properties |
| density | 1.361±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in H2O; insoluble in DMSO; ≥19.2 mg/mL in EtOH | | form | Solid | | pka | 7.73±0.50(Predicted) | | color | White to off-white |
| | Kif15-IN-1 Usage And Synthesis |
| Uses | Kif15-IN-1 is an inhibitor of the mitotic Kinesin family member 15 (Kif15), and is used for the research of cellular proliferative diseases. | | Biological Activity | kif15-in-1, a potent kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].kif15,also known as kinesin-12 and hklp2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.kif15 is involved in maintaining bipolar microtubulespindle apparatusin dividing cells and shares redundant functions with kif11 [3]. | | IC 50 | KIF15 | | references | [1]. preparation of quinazolinediones as kif15 kinesin inhibitors for treating cellular proliferative disorders. pat. appl. publ. (2004), us 20040053948 a1 20040318.
[2]. buster d w, baird d h, yu w, et al. expression of the mitotic kinesin kif15 in postmitotic neurons: implications for neuronal migration and development[j]. journal of neurocytology, 2003, 32(1): 79-96.
[3]. vanneste d, takagi m, imamoto n, et al. the role of hklp2 in the stabilization and maintenance of spindle bipolarity[j]. current biology, 2009, 19(20): 1712-1717. |
| | Kif15-IN-1 Preparation Products And Raw materials |
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