SU-11752 manufacturers
- SU-11752
-
- $1820.00
-
2026-05-11
- CAS:688036-19-3
- Purity:
- Supply Ability: 10g
|
| | SU-11752 Basic information |
| Product Name: | SU-11752 | | Synonyms: | SU-11752;1H-Pyrrole-3-propanoic acid, 5-[[1,2-dihydro-2-oxo-5-[(phenylamino)sulfonyl]-3H-indol-3-ylidene]methyl]-2,4-diethyl- | | CAS: | 688036-19-3 | | MF: | C26H27N3O5S | | MW: | 493.58 | | EINECS: | | | Product Categories: | | | Mol File: | 688036-19-3.mol |  |
| | SU-11752 Chemical Properties |
| density | 1.387±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 4.644±0.10(predicted) |
| | SU-11752 Usage And Synthesis |
| Description | SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited. | | Uses | SU-11752 is an inhibitor for DNA-dependent protein kinase (DNA-PK) with an IC50 of 0.13 μM. SU-11752 inhibits PI3K p110γ kinase with IC50 of 1.1 μM. SU-11752 binds competitively for ATP-site in DNA-PK, results in inhibition of intracellular DNA double-strand break repair and increases the sensitivity of cells to radiotherapy[1]. | | IC 50 | DNA-PK: 0.13 μM (IC50); p110γ: 1.1 μM (IC50) | | References | [1] Ismail IH, et al., SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization. Oncogene. 2004 Jan 29;23(4):873-82. DOI:10.1038/sj.onc.1207303 |
| | SU-11752 Preparation Products And Raw materials |
|