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Product Name:AF-DX 384
CAS:118290-26-9
Purity:98% Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide manufacturers
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| | N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Basic information |
| Product Name: | N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide | | Synonyms: | AF-DX 384 Free Base;AF-DX-384; AF-DX384;N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide;N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide;11H-Pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo- | | CAS: | 118290-26-9 | | MF: | C27H38N6O2 | | MW: | 478.63 | | EINECS: | | | Product Categories: | | | Mol File: | 118290-26-9.mol | ![N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Structure](CAS/20180629/GIF/118290-26-9.gif) |
| | N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Chemical Properties |
| Boiling point | 618.4±55.0 °C(Predicted) | | density | 1.144±0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMSO: soluble10mg/mL, clear (warmed) | | form | powder | | pka | 11.55±0.20(Predicted) | | color | white to beige | | InChIKey | MZDYABXXPZNUCT-UHFFFAOYSA-N | | SMILES | N4(C(CCCC4)CN(CCC)CCC)CCNC(=O)[n]1c2ncccc2[nH][c](c3c1cccc3)=O |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Usage And Synthesis |
| Description | AF-DX 384 is an antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis = 6.03 and 10 nM, respectively). It is selective for M2 and M4 over M1, M3, and M5 receptors (Kis = 30.9, 66.07, and 537.03 nM, respectively). AF-DX 384 increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo when infused locally at a concentration of 1 μM and in the cortex when administered intraperitoneally at a dose of 5 mg/kg. It reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine . | | Uses | AF-DX 384 is a potent mAChR M2/mAChR M4selective antagonist. | | Definition | ChEBI: N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide is a benzodiazepine. | | storage | Store at RT | | References | [1] F DRJE. Antagonist binding profiles of five cloned human muscarinic receptor subtypes.[J]. Journal of Pharmacology and Experimental Therapeutics, 1991, 256 2: 727-733.
[2] M.G VANNUCCHI. Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats[J]. Neuroscience, 1997, 79 3: Pages 837-846. DOI: 10.1016/s0306-4522(97)00091-2 |
| | N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Preparation Products And Raw materials |
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