VU6005649 manufacturers
- VU6005649
-
- $45.00
-
2026-08-08
- CAS:2137047-43-7
- Purity: 99.87%
- Supply Ability: 10g
- VU6005649
-
- $45.00
-
2026-08-08
- CAS:2137047-43-7
- Purity: 99.87%
- Supply Ability: 10g
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| | VU6005649 Basic information |
| Product Name: | VU6005649 | | Synonyms: | VU6005649;VU-6005649;VU 6005649;VU6005649; VU-6005649; VU 6005649;CS-2729;Pyrazolo[1,5-a]pyrimidine, 3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)-;Inhibitor,inhibit,VU6005649,mGluR,Metabotropic glutamate receptors,VU 6005649,VU-6005649;3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine;VU6005649, 10 mM in DMSO | | CAS: | 2137047-43-7 | | MF: | C16H12F5N3O | | MW: | 357.28 | | EINECS: | | | Product Categories: | | | Mol File: | 2137047-43-7.mol |  |
| | VU6005649 Chemical Properties |
| density | 1.43±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | -1.73±0.30(Predicted) | | form | Solid | | color | Light yellow to yellow | | InChI | InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3 | | InChIKey | NYBZCKAQIIPSDS-UHFFFAOYSA-N | | SMILES | C12=C(C3=CC=C(OC)C(F)=C3F)C(C)=NN1C(C(F)(F)F)=CC(C)=N2 |
| | VU6005649 Usage And Synthesis |
| Uses | VU 6005649, is a novel mGlu7/8 receptor agonist with excellent CNS penetration (Kp 1.9-5.8 and Kp,uu 0.4-1.4). | | in vivo | When VU6005649 (compound 9f) is dosed at 30 mg/kg IP in 10% Tween 80/H2O (0.75 mg/kg. s.c. amphetamine), no efficacy is observed in this assay. VU6005649 shows modest but significant pro-cognitive effects on associative learning in wild-type mice and the first example of efficacy of an mGlu7/8 positive allosteric modulator (PAM) in this model[1]. | | IC 50 | mGlu7 Receptor: 0.65 μM (EC50); mGlu8 Receptor: 2.6 μM (EC50) | | storage | Store at -20°C |
| | VU6005649 Preparation Products And Raw materials |
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