盐酸双环维林
| 中文名称 | 盐酸双环维林 |
|---|---|
| 中文同义词 | 盐酸双环维林杂质;盐酸双环胺;盐酸双环维林;双环维林盐酸盐[受控];盐酸双环胺DICYCLOVERINE HYDROCHLORIDE;双环胺盐酸盐;盐酸双环维林 USP标准品;DICYCLOVERINE HCL (DICYCLOMINE HCL) |
| 英文名称 | DICYCLOMINE HYDROCHLORIDE |
| 英文同义词 | [BICYCLOHEXYL]-1-CARBOXYLIC ACID DIETHYLAMINOETHYL ESTER HYDROCHLORIDE;DICYCLOMINE HCL;DICYCLOMINE HYDROCHLORIDE;LABOTEST-BB LT00771946;[1,1'-BICYCLOHEXYL]-1-CARBOXYLIC ACID 2-(DIETHYLAMINO) ETHYL ESTER, HYDROCHLORIDE;(1,1’-bicyclohexyl)-1-carboxylicacid,2-(diethylamino)ethylester,hydrochlo;[2-[[[1,1'-bicyclohexyl]-1-ylcarbonyl]oxy]ethyl]diethylammonium chloride;Bentyl) |
| CAS号 | 67-92-5 |
| 分子式 | C19H36ClNO2 |
| 分子量 | 345.95 |
| EINECS号 | 200-671-1 |
| 相关类别 | 小分子抑制剂;中药对照品;标准品;Intermediates & Fine Chemicals;Pharmaceuticals;BENTYL |
| Mol文件 | 67-92-5.mol |
| 结构式 |  |
盐酸双环维林 性质
| 熔点 | 164-166°C |
|---|---|
| 储存条件 | -20°C Freezer |
| 溶解度 | H2O:50 mg/mL |
| 形态 | 粉末 |
| 颜色 | 米白色 |
| 水溶解性 | H2O: 50mg/mL |
| BCS Class | 2/4 |
| InChI | 1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H |
| InChIKey | GUBNMFJOJGDCEL-UHFFFAOYSA-N |
| SMILES | CCN(CCOC(C1(C2CCCCC2)CCCCC1)=O)CC.[Cl] |
| EPA化学物质信息 | 2-Diethylaminoethyl bicyclohexyl-1-carboxylate hydrochloride (67-92-5) |
Dicyclomine hydrochloride 是一种有效的口服活性毒蕈碱胆碱能受体 (muscarinic cholinergic receptors) 拮抗剂。Dicyclomine hydrochloride 对 M1 受体亚型 (Ki=5.1 nM) 和 M2 受体亚型 (Ki=54.6 nM) 在刷缘膜和基底质膜中均表现出较高的亲和力。Dicyclomine hydrochloride是一种抗痉挛试剂，在体内可缓解胃肠道平滑肌痉挛。
Ki: 5.1 nM (muscarinic M1 receptor subtype in brush-border membrane)Ki: 54.6 nM (muscarinic M2 receptor subtype in basal plasma membrane
Dicyclomine hydrochloride (intraperitoneal injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice.Dicyclomine hydrochloride (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks.
| Animal Model: | C57Bl/6 mice |
| Dosage: | 2.0, 4.0, and 8.0 mg/kg |
| Administration: | Intraperitoneal injection; daily; 7 days |
| Result: | Produced impairments due to actions of the agent outside of the hippocampus. |
类别
有毒物品毒性分级
中毒急性毒性
口服-大鼠 LD50: 625 毫克/公斤; 口服-小鼠 LD50: 625 毫克/公斤可燃性危险特性
可燃;燃烧产生有毒氮氧化物和氯化氢烟雾;病人用药副作用;僵硬,呼吸困难,苍白储运特性
通风低温干燥灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 22-36/37/38 |
| 安全说明 | 26-36 |
| WGK Germany | 3 |
| RTECS号 | DT7350000 |
| TSCA | TSCA listed |
| 海关编码 | 2922199695 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 经口 眼部刺激 类别2 经皮刺激 类别2 特异性靶器官毒性-一次接触，类别3 |
| 毒性 | LD50 orl-rat: 1290 mg/kg DRUGAY 6,317,82 |
| 提供商 | 语言 |
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英文
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